Topiramate and asymptomatic ocular angle narrowing: A prospective pilot study

D. Y.L. Leung, H. Leung, N. Baig, P. Kwan, Y. Y.Y. Kwong, K. S. Wong, D. S.C. Lam

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)


Purpose: To investigate whether subclinical ciliochoroidal effusion and resulting asymptomatic angle narrowing occurs in patients taking topiramate, by ultrasound biomicroscopy (UBM).Methods: Chinese patients aged 18-75 years for whom topiramate was indicated were recruited. Examinations including UBM were performed before and 4 weeks after commencement of topiramate.Results: In this pilot of 20 eyes of 20 patients, there were no statistically significant changes in the angle parameters noted on gonioscopy or UBM, including anterior chamber depth, angle-opening distance at 500 m, trabecular ciliary process distance, trabecular-iris angle, and scleral thickness.Conclusion: Short-term use of topiramate does not induce asymptomatic angle narrowing.

Original languageEnglish
Pages (from-to)2079-2081
Number of pages3
Issue number11
Publication statusPublished - 1 Jan 2009
Externally publishedYes


  • Acute angle-closure glaucoma
  • Topiramate
  • Ultrasound biomicroscopy

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