Topiramate and asymptomatic ocular angle narrowing: A prospective pilot study

D. Y.L. Leung; H. Leung; N. Baig; P. Kwan; Y. Y.Y. Kwong; K. S. Wong; D. S.C. Lam

doi:10.1038/eye.2009.93

Topiramate and asymptomatic ocular angle narrowing: A prospective pilot study

D. Y.L. Leung, H. Leung, N. Baig, P. Kwan, Y. Y.Y. Kwong, K. S. Wong, D. S.C. Lam

Research output: Contribution to journal › Article › Research › peer-review

10 Citations (Scopus)

Abstract

Purpose: To investigate whether subclinical ciliochoroidal effusion and resulting asymptomatic angle narrowing occurs in patients taking topiramate, by ultrasound biomicroscopy (UBM).Methods: Chinese patients aged 18-75 years for whom topiramate was indicated were recruited. Examinations including UBM were performed before and 4 weeks after commencement of topiramate.Results: In this pilot of 20 eyes of 20 patients, there were no statistically significant changes in the angle parameters noted on gonioscopy or UBM, including anterior chamber depth, angle-opening distance at 500 m, trabecular ciliary process distance, trabecular-iris angle, and scleral thickness.Conclusion: Short-term use of topiramate does not induce asymptomatic angle narrowing.

Original language	English
Pages (from-to)	2079-2081
Number of pages	3
Journal	Eye
Volume	23
Issue number	11
DOIs	https://doi.org/10.1038/eye.2009.93
Publication status	Published - 1 Jan 2009
Externally published	Yes

Keywords

Acute angle-closure glaucoma
Topiramate
Ultrasound biomicroscopy

Access to Document

10.1038/eye.2009.93

Link to publication in Scopus

Cite this

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title = "Topiramate and asymptomatic ocular angle narrowing: A prospective pilot study",

abstract = "Purpose: To investigate whether subclinical ciliochoroidal effusion and resulting asymptomatic angle narrowing occurs in patients taking topiramate, by ultrasound biomicroscopy (UBM).Methods: Chinese patients aged 18-75 years for whom topiramate was indicated were recruited. Examinations including UBM were performed before and 4 weeks after commencement of topiramate.Results: In this pilot of 20 eyes of 20 patients, there were no statistically significant changes in the angle parameters noted on gonioscopy or UBM, including anterior chamber depth, angle-opening distance at 500 m, trabecular ciliary process distance, trabecular-iris angle, and scleral thickness.Conclusion: Short-term use of topiramate does not induce asymptomatic angle narrowing.",

keywords = "Acute angle-closure glaucoma, Topiramate, Ultrasound biomicroscopy",

author = "Leung, {D. Y.L.} and H. Leung and N. Baig and P. Kwan and Kwong, {Y. Y.Y.} and Wong, {K. S.} and Lam, {D. S.C.}",

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doi = "10.1038/eye.2009.93",

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TY - JOUR

T1 - Topiramate and asymptomatic ocular angle narrowing

T2 - A prospective pilot study

AU - Leung, D. Y.L.

AU - Leung, H.

AU - Baig, N.

AU - Kwan, P.

AU - Kwong, Y. Y.Y.

AU - Wong, K. S.

AU - Lam, D. S.C.

PY - 2009/1/1

Y1 - 2009/1/1

N2 - Purpose: To investigate whether subclinical ciliochoroidal effusion and resulting asymptomatic angle narrowing occurs in patients taking topiramate, by ultrasound biomicroscopy (UBM).Methods: Chinese patients aged 18-75 years for whom topiramate was indicated were recruited. Examinations including UBM were performed before and 4 weeks after commencement of topiramate.Results: In this pilot of 20 eyes of 20 patients, there were no statistically significant changes in the angle parameters noted on gonioscopy or UBM, including anterior chamber depth, angle-opening distance at 500 m, trabecular ciliary process distance, trabecular-iris angle, and scleral thickness.Conclusion: Short-term use of topiramate does not induce asymptomatic angle narrowing.

AB - Purpose: To investigate whether subclinical ciliochoroidal effusion and resulting asymptomatic angle narrowing occurs in patients taking topiramate, by ultrasound biomicroscopy (UBM).Methods: Chinese patients aged 18-75 years for whom topiramate was indicated were recruited. Examinations including UBM were performed before and 4 weeks after commencement of topiramate.Results: In this pilot of 20 eyes of 20 patients, there were no statistically significant changes in the angle parameters noted on gonioscopy or UBM, including anterior chamber depth, angle-opening distance at 500 m, trabecular ciliary process distance, trabecular-iris angle, and scleral thickness.Conclusion: Short-term use of topiramate does not induce asymptomatic angle narrowing.

KW - Acute angle-closure glaucoma

KW - Topiramate

KW - Ultrasound biomicroscopy

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