Topical prostaglandin analogues do not affect selective laser trabeculoplasty outcomes

D. Singh, M. A. Coote, F. O'Hare, M. J. Walland, S. Ghosh, J. Xie, J. B. Ruddle, J. G. Crowston

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PurposeTo investigate the effect of topical prostaglandin analogue use on the efficacy of selective laser trabeculoplasty (SLT) intraocular pressure (IOP) lowering in patients with open-angle glaucoma.Patients and MethodsThis retrospective study included 123 consecutive patients who underwent 180° SLT for the first time. Eyes were grouped into those that received prostaglandin analogues before and after SLT (n = 74) and those that did not (n = 49). The main outcome measure was IOP lowering after SLT. Success was defined as ≥ 20% reduction in IOP without further glaucoma intervention.ResultsThere was no significant difference in IOP lowering at 6 months post-laser between the prostaglandin and non-prostaglandin groups (3.94.8 vs4.63.6 mm Hg, P = 0.43). Long-term SLT success rates were also not significantly different between the treatment groups (Kaplan-Meier survival analysis, P = 0.68). IOP lowering at 6 months was similar in eyes that received no glaucoma medications, monotherapy with or without a prostaglandin analogue, or combination therapy with or without prostaglandin analogues (P = 0.81). Logistic regression analysis showed that various patient characteristics including age, sex, type of glaucoma, previous glaucoma surgery, and other glaucoma risk factors did not predict a successful SLT outcome. However, higher pre-operative IOP was found to predict SLT success (odds ratio1.12, 95% CI1.02-1.24, P = 0.02).ConclusionThe IOP lowering efficacy of SLT is not influenced by the use of topical prostaglandin analogues.

Original languageEnglish
Pages (from-to)2194-2199
Number of pages6
Issue number12
Publication statusPublished - 1 Jan 2009
Externally publishedYes


  • Glaucoma
  • Intraocular pressure
  • Prostaglandin analogues
  • Selective laser trabeculoplasty

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