Topical Aminosalicylic Acid Improves Keratinocyte Differentiation in an Inducible Mouse Model of Harlequin Ichthyosis

Denny L. Cottle, Gloria M.A. Ursino, Lynelle K. Jones, Ming Shen Tham, Allara K. Zylberberg, Ian M. Smyth

Research output: Contribution to journalArticleResearchpeer-review


Harlequin ichthyosis arises because of the loss of lipid transport in the skin. Cottle et al. demonstrate that the treatment of mouse models of this disease with anti-inflammatory aminosalicylic acid drugs improves skin differentiation and protective barrier function.

Original languageEnglish
Article number100129
Number of pages16
JournalCell Reports Medicine
Issue number8
Publication statusPublished - 17 Nov 2020


  • 4ASA
  • 5ASA
  • ABCA12
  • acitretin
  • aminosalicylic acid
  • epidermal differentiation
  • harlequin ichthyosis
  • mesalamine
  • skin barrier function

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