Topical Aminosalicylic Acid Improves Keratinocyte Differentiation in an Inducible Mouse Model of Harlequin Ichthyosis

Denny L. Cottle; Gloria M.A. Ursino; Lynelle K. Jones; Ming Shen Tham; Allara K. Zylberberg; Ian M. Smyth

doi:10.1016/j.xcrm.2020.100129

Topical Aminosalicylic Acid Improves Keratinocyte Differentiation in an Inducible Mouse Model of Harlequin Ichthyosis

Denny L. Cottle, Gloria M.A. Ursino, Lynelle K. Jones, Ming Shen Tham, Allara K. Zylberberg, Ian M. Smyth

Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)

Abstract

Harlequin ichthyosis arises because of the loss of lipid transport in the skin. Cottle et al. demonstrate that the treatment of mouse models of this disease with anti-inflammatory aminosalicylic acid drugs improves skin differentiation and protective barrier function.

Original language	English
Article number	100129
Number of pages	16
Journal	Cell Reports Medicine
Volume	1
Issue number	8
DOIs	https://doi.org/10.1016/j.xcrm.2020.100129
Publication status	Published - 17 Nov 2020

Keywords

4ASA
5ASA
ABCA12
acitretin
aminosalicylic acid
epidermal differentiation
harlequin ichthyosis
mesalamine
skin barrier function

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10.1016/j.xcrm.2020.100129Licence: CC BY-NC-ND

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title = "Topical Aminosalicylic Acid Improves Keratinocyte Differentiation in an Inducible Mouse Model of Harlequin Ichthyosis",

abstract = "Harlequin ichthyosis arises because of the loss of lipid transport in the skin. Cottle et al. demonstrate that the treatment of mouse models of this disease with anti-inflammatory aminosalicylic acid drugs improves skin differentiation and protective barrier function.",

keywords = "4ASA, 5ASA, ABCA12, acitretin, aminosalicylic acid, epidermal differentiation, harlequin ichthyosis, mesalamine, skin barrier function",

author = "Cottle, {Denny L.} and Ursino, {Gloria M.A.} and Jones, {Lynelle K.} and Tham, {Ming Shen} and Zylberberg, {Allara K.} and Smyth, {Ian M.}",

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AU - Jones, Lynelle K.

AU - Tham, Ming Shen

AU - Zylberberg, Allara K.

AU - Smyth, Ian M.

PY - 2020/11/17

Y1 - 2020/11/17

N2 - Harlequin ichthyosis arises because of the loss of lipid transport in the skin. Cottle et al. demonstrate that the treatment of mouse models of this disease with anti-inflammatory aminosalicylic acid drugs improves skin differentiation and protective barrier function.

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KW - ABCA12

KW - acitretin

KW - aminosalicylic acid

KW - epidermal differentiation

KW - harlequin ichthyosis

KW - mesalamine

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Topical Aminosalicylic Acid Improves Keratinocyte Differentiation in an Inducible Mouse Model of Harlequin Ichthyosis

Abstract

Keywords

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Other files and links

Modulating inflammation as a therapy for Harlequin Ichthyosis

Cite this

Topical Aminosalicylic Acid Improves Keratinocyte Differentiation in an Inducible Mouse Model of Harlequin Ichthyosis

Abstract

Keywords

Access to Document

Other files and links

Projects

Modulating inflammation as a therapy for Harlequin Ichthyosis

Cite this