Tools for predicting patient-reported outcomes in prostate cancer patients undergoing radical prostatectomy

a systematic review of prognostic accuracy and validity

M. E. O'Callaghan, Elspeth Raymond, J. Campbell, A. D. Vincent, Kerri Beckmann, D. Roder, S. Evans, J. McNeil, J. Millar, J. Zalcberg, M. Borg, Kim Moretti

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

Background:Radical prostatectomy is a common surgical procedure performed to treat prostate cancer. Patient-reported outcomes after surgery include urinary incontinence, erectile dysfunction, decreased quality of life and psychological effects. Predictive tools to assess the likelihood of an individual experiencing various patient-reported outcomes have been developed to aid decision-making when selecting treatment.Methods:A systematic review was undertaken to identify all papers describing tools for the prediction of patient-reported outcome measures in men with prostate cancer treated with radical prostatectomy. To be eligible for inclusion, papers had to provide a summary measure of accuracy. PubMed and EMBASE were searched from July 2007. Title/abstract screening, and full-text review were undertaken by two reviewers, while data extraction and critical appraisal was performed by a single reviewer.Results:The search strategy identified 3217 potential studies, of which 191 progressed to full-text review and 14 were included. From these studies, 27 tools in total were identified, of which 18 predicted urinary symptoms, six predicted erectile function and one predicted freedom from a group of three outcomes (‘trifecta’) (biochemical recurrence, incontinence and erectile dysfunction). On the basis of tool accuracy (>70%) and external validation, two tools predicting incontinence and two tools predicting erectile dysfunction are ready for implementation.Conclusions:A small number of tools for the prediction of patient-reported outcomes following radical prostatectomy have been developed. Four tools were found to have adequate accuracy and validation and are ready for implementation for the prediction of urinary incontinence and erectile dysfunction.Prostate Cancer and Prostatic Diseases advance online publication, 6 June 2017; doi:10.1038/pcan.2017.28.

Original languageEnglish
Pages (from-to)378-388
Number of pages11
JournalProstate Cancer and Prostatic Diseases
Volume20
DOIs
Publication statusPublished - 6 Jun 2017

Keywords

  • outcomes research
  • prostate cancer

Cite this

@article{ea0765936997455f8cda2d7d1546f549,
title = "Tools for predicting patient-reported outcomes in prostate cancer patients undergoing radical prostatectomy: a systematic review of prognostic accuracy and validity",
abstract = "Background:Radical prostatectomy is a common surgical procedure performed to treat prostate cancer. Patient-reported outcomes after surgery include urinary incontinence, erectile dysfunction, decreased quality of life and psychological effects. Predictive tools to assess the likelihood of an individual experiencing various patient-reported outcomes have been developed to aid decision-making when selecting treatment.Methods:A systematic review was undertaken to identify all papers describing tools for the prediction of patient-reported outcome measures in men with prostate cancer treated with radical prostatectomy. To be eligible for inclusion, papers had to provide a summary measure of accuracy. PubMed and EMBASE were searched from July 2007. Title/abstract screening, and full-text review were undertaken by two reviewers, while data extraction and critical appraisal was performed by a single reviewer.Results:The search strategy identified 3217 potential studies, of which 191 progressed to full-text review and 14 were included. From these studies, 27 tools in total were identified, of which 18 predicted urinary symptoms, six predicted erectile function and one predicted freedom from a group of three outcomes (‘trifecta’) (biochemical recurrence, incontinence and erectile dysfunction). On the basis of tool accuracy (>70{\%}) and external validation, two tools predicting incontinence and two tools predicting erectile dysfunction are ready for implementation.Conclusions:A small number of tools for the prediction of patient-reported outcomes following radical prostatectomy have been developed. Four tools were found to have adequate accuracy and validation and are ready for implementation for the prediction of urinary incontinence and erectile dysfunction.Prostate Cancer and Prostatic Diseases advance online publication, 6 June 2017; doi:10.1038/pcan.2017.28.",
keywords = "outcomes research, prostate cancer",
author = "O'Callaghan, {M. E.} and Elspeth Raymond and J. Campbell and Vincent, {A. D.} and Kerri Beckmann and D. Roder and S. Evans and J. McNeil and J. Millar and J. Zalcberg and M. Borg and Kim Moretti",
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Tools for predicting patient-reported outcomes in prostate cancer patients undergoing radical prostatectomy : a systematic review of prognostic accuracy and validity. / O'Callaghan, M. E.; Raymond, Elspeth; Campbell, J.; Vincent, A. D.; Beckmann, Kerri; Roder, D.; Evans, S.; McNeil, J.; Millar, J.; Zalcberg, J.; Borg, M.; Moretti, Kim.

In: Prostate Cancer and Prostatic Diseases, Vol. 20, 06.06.2017, p. 378-388.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Tools for predicting patient-reported outcomes in prostate cancer patients undergoing radical prostatectomy

T2 - a systematic review of prognostic accuracy and validity

AU - O'Callaghan, M. E.

AU - Raymond, Elspeth

AU - Campbell, J.

AU - Vincent, A. D.

AU - Beckmann, Kerri

AU - Roder, D.

AU - Evans, S.

AU - McNeil, J.

AU - Millar, J.

AU - Zalcberg, J.

AU - Borg, M.

AU - Moretti, Kim

PY - 2017/6/6

Y1 - 2017/6/6

N2 - Background:Radical prostatectomy is a common surgical procedure performed to treat prostate cancer. Patient-reported outcomes after surgery include urinary incontinence, erectile dysfunction, decreased quality of life and psychological effects. Predictive tools to assess the likelihood of an individual experiencing various patient-reported outcomes have been developed to aid decision-making when selecting treatment.Methods:A systematic review was undertaken to identify all papers describing tools for the prediction of patient-reported outcome measures in men with prostate cancer treated with radical prostatectomy. To be eligible for inclusion, papers had to provide a summary measure of accuracy. PubMed and EMBASE were searched from July 2007. Title/abstract screening, and full-text review were undertaken by two reviewers, while data extraction and critical appraisal was performed by a single reviewer.Results:The search strategy identified 3217 potential studies, of which 191 progressed to full-text review and 14 were included. From these studies, 27 tools in total were identified, of which 18 predicted urinary symptoms, six predicted erectile function and one predicted freedom from a group of three outcomes (‘trifecta’) (biochemical recurrence, incontinence and erectile dysfunction). On the basis of tool accuracy (>70%) and external validation, two tools predicting incontinence and two tools predicting erectile dysfunction are ready for implementation.Conclusions:A small number of tools for the prediction of patient-reported outcomes following radical prostatectomy have been developed. Four tools were found to have adequate accuracy and validation and are ready for implementation for the prediction of urinary incontinence and erectile dysfunction.Prostate Cancer and Prostatic Diseases advance online publication, 6 June 2017; doi:10.1038/pcan.2017.28.

AB - Background:Radical prostatectomy is a common surgical procedure performed to treat prostate cancer. Patient-reported outcomes after surgery include urinary incontinence, erectile dysfunction, decreased quality of life and psychological effects. Predictive tools to assess the likelihood of an individual experiencing various patient-reported outcomes have been developed to aid decision-making when selecting treatment.Methods:A systematic review was undertaken to identify all papers describing tools for the prediction of patient-reported outcome measures in men with prostate cancer treated with radical prostatectomy. To be eligible for inclusion, papers had to provide a summary measure of accuracy. PubMed and EMBASE were searched from July 2007. Title/abstract screening, and full-text review were undertaken by two reviewers, while data extraction and critical appraisal was performed by a single reviewer.Results:The search strategy identified 3217 potential studies, of which 191 progressed to full-text review and 14 were included. From these studies, 27 tools in total were identified, of which 18 predicted urinary symptoms, six predicted erectile function and one predicted freedom from a group of three outcomes (‘trifecta’) (biochemical recurrence, incontinence and erectile dysfunction). On the basis of tool accuracy (>70%) and external validation, two tools predicting incontinence and two tools predicting erectile dysfunction are ready for implementation.Conclusions:A small number of tools for the prediction of patient-reported outcomes following radical prostatectomy have been developed. Four tools were found to have adequate accuracy and validation and are ready for implementation for the prediction of urinary incontinence and erectile dysfunction.Prostate Cancer and Prostatic Diseases advance online publication, 6 June 2017; doi:10.1038/pcan.2017.28.

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DO - 10.1038/pcan.2017.28

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SN - 1365-7852

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