Toll-like receptors: structural pieces of a curve-shaped puzzle

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Abstract

The toll-like receptors are responsible for recognizing invading pathogens and triggering a primary innate immune response by initiating a signalling pathway that ultimately leads to the activation of nuclear factor-B (NF-B). NF-B induces the transcription of many genes that regulate both the inflammatory response and interferons that help control the development of adaptive immunity. In this review, we concentrate on the structure and function of toll-like receptors and our current understanding of the complexities of ligand binding, receptor dimerization and signal transduction.
Original languageEnglish
Pages (from-to)406 - 410
Number of pages5
JournalImmunology and Cell Biology
Volume85
Issue number6
Publication statusPublished - 2007

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