Toll-like receptors at the ocular surface

Eric Pearlman, Angela Johnson, Gautam Adhikary, Yan Sun, Holly R Chinnery, Todd Fox, Mark Kester, Paul G McMenamin

Research output: Contribution to journalArticleResearchpeer-review

90 Citations (Scopus)

Abstract

The Toll-like receptor (TLR) family of pathogen recognition molecules has an important role in recognizing microbial pathogens and microbial breakdown products. Activation of TLRs in the corneal epithelium induces CXC chemokine production and recruitment of neutrophils to the corneal stroma. Although essential for pathogen killing, neutrophils can cause extensive tissue damage, leading to visual impairment and blindness. In this review, we examine the role of TLRs in microbial keratitis and in noninfectious corneal inflammation, most commonly associated with contact lens wear. we present recent findings on TLR signaling pathways in the cornea, including MyD88- and TRIF-dependent responses and discuss the role of resident macrophages and dendritic cells. Finally, we examine the potential for targeting the TLR pathway as a potential therapeutic intervention for microbial keratitis and contact lens-associated corneal inflammation.
Original languageEnglish
Pages (from-to)108 - 116
Number of pages9
JournalOcular Surface
Volume6
Issue number3
Publication statusPublished - 2008
Externally publishedYes

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