Toll-like receptors as interferon-regulated genes and their role in disease

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Abstract

The Toll-like receptors (TLRs) are innate sensors that recognize both microbial and endogenous ligands, initiating the host defense response. TLRs initiate the potent proinflammatory response to infection, are the target for adjuvants, and are essential for the establishment and maturation of adaptive immunity. As such they have been the interest of widespread research and the target of therapeutic intervention on multiple diseases. It has become apparent that expression of a subset of TLRs (TLR1, TLR2, TLR3, TLR5, and TLR7) is induced by Type I interferons (IFN). The role and impact of IFN expression on TLR responses is therefore critical in understanding the role of TLRs in disease, particularly as IFN itself is a downstream gene induced by specific TLRs. In this review we discuss the function and role of IFN-regulated TLRs in disease and how the role of IFN may impact upon TLR induction of the immune response in diseases, particularly in mouse models.
Original languageEnglish
Pages (from-to)13 - 25
Number of pages13
JournalJournal of Interferon and Cytokine Research
Volume31
Issue number1
DOIs
Publication statusPublished - 2011

Cite this

@article{7efc0a8eb386445788c9eac7788a16ae,
title = "Toll-like receptors as interferon-regulated genes and their role in disease",
abstract = "The Toll-like receptors (TLRs) are innate sensors that recognize both microbial and endogenous ligands, initiating the host defense response. TLRs initiate the potent proinflammatory response to infection, are the target for adjuvants, and are essential for the establishment and maturation of adaptive immunity. As such they have been the interest of widespread research and the target of therapeutic intervention on multiple diseases. It has become apparent that expression of a subset of TLRs (TLR1, TLR2, TLR3, TLR5, and TLR7) is induced by Type I interferons (IFN). The role and impact of IFN expression on TLR responses is therefore critical in understanding the role of TLRs in disease, particularly as IFN itself is a downstream gene induced by specific TLRs. In this review we discuss the function and role of IFN-regulated TLRs in disease and how the role of IFN may impact upon TLR induction of the immune response in diseases, particularly in mouse models.",
author = "Jing Khoo and Samuel Forster and Ashley Mansell",
year = "2011",
doi = "10.1089/jir.2010.0095",
language = "English",
volume = "31",
pages = "13 -- 25",
journal = "Journal of Interferon and Cytokine Research",
issn = "1079-9907",
publisher = "Mary Ann Liebert Inc",
number = "1",

}

Toll-like receptors as interferon-regulated genes and their role in disease. / Khoo, Jing; Forster, Samuel; Mansell, Ashley.

In: Journal of Interferon and Cytokine Research, Vol. 31, No. 1, 2011, p. 13 - 25.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Toll-like receptors as interferon-regulated genes and their role in disease

AU - Khoo, Jing

AU - Forster, Samuel

AU - Mansell, Ashley

PY - 2011

Y1 - 2011

N2 - The Toll-like receptors (TLRs) are innate sensors that recognize both microbial and endogenous ligands, initiating the host defense response. TLRs initiate the potent proinflammatory response to infection, are the target for adjuvants, and are essential for the establishment and maturation of adaptive immunity. As such they have been the interest of widespread research and the target of therapeutic intervention on multiple diseases. It has become apparent that expression of a subset of TLRs (TLR1, TLR2, TLR3, TLR5, and TLR7) is induced by Type I interferons (IFN). The role and impact of IFN expression on TLR responses is therefore critical in understanding the role of TLRs in disease, particularly as IFN itself is a downstream gene induced by specific TLRs. In this review we discuss the function and role of IFN-regulated TLRs in disease and how the role of IFN may impact upon TLR induction of the immune response in diseases, particularly in mouse models.

AB - The Toll-like receptors (TLRs) are innate sensors that recognize both microbial and endogenous ligands, initiating the host defense response. TLRs initiate the potent proinflammatory response to infection, are the target for adjuvants, and are essential for the establishment and maturation of adaptive immunity. As such they have been the interest of widespread research and the target of therapeutic intervention on multiple diseases. It has become apparent that expression of a subset of TLRs (TLR1, TLR2, TLR3, TLR5, and TLR7) is induced by Type I interferons (IFN). The role and impact of IFN expression on TLR responses is therefore critical in understanding the role of TLRs in disease, particularly as IFN itself is a downstream gene induced by specific TLRs. In this review we discuss the function and role of IFN-regulated TLRs in disease and how the role of IFN may impact upon TLR induction of the immune response in diseases, particularly in mouse models.

UR - http://online.liebertpub.com/doi/pdf/10.1089/jir.2010.0095

U2 - 10.1089/jir.2010.0095

DO - 10.1089/jir.2010.0095

M3 - Article

VL - 31

SP - 13

EP - 25

JO - Journal of Interferon and Cytokine Research

JF - Journal of Interferon and Cytokine Research

SN - 1079-9907

IS - 1

ER -