Toll-like receptor 2 induces Th17 myeloperoxidase autoimmunity while Toll-like receptor 9 drives Th1 autoimmunity in murine vasculitis

Shaun Andrew Summers, Oliver Steinmetz, Poh-Yi Gan, Joshua Ooi, Dragana Odobasic, Arthur Kitching, Stephen Holdsworth

Research output: Contribution to journalArticleResearchpeer-review

49 Citations (Scopus)

Abstract

Autoantibodies constitute the hallmark of antineutrophil cytoplasmic antibody-associated vasculitis (AAV); however, CD4+ T cells play an essential role in the development of autoimmunity. Infection is associated with vasculitis, with Toll-like receptors (TLRs) a potential link between infection and autoimmunity. This study was undertaken to investigate the role of TLR ligation on cellular and humoral autoimmunity and glomerular injury in experimental myeloperoxidase (MPO)-induced AAV. METHODS: We analyzed autoimmune responses in wild-type mice immunized with MPO alone or coimmunized with MPO and a TLR-2 or TLR-9 ligand. The major vascular injury found in human disease, glomerulonephritis with focal necrosis, was triggered by administering a subnephritogenic dose of nephrotoxic serum.
Original languageEnglish
Pages (from-to)1124 - 1135
Number of pages12
JournalArthritis & Rheumatism
Volume63
Issue number4
DOIs
Publication statusPublished - 2011

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