TY - JOUR
T1 - Tocotrienol-rich vitamin e from palm oil (Tocovid) and its effects in diabetes and diabetic retinopathy
T2 - A pilot phase ii clinical trial
AU - Chiew, Yilynn
AU - Tan, Suzanne May Quinn
AU - Ahmad, Badariah
AU - Khor, Sim Ee
AU - Kadir, Khalid Abdul
N1 - Funding Information:
This work was supported by Monash University Malaysia under the Tropical Medicine and Biology (TMB) grant (Grant number: TMB-2018-CR3185140918-Su-zTMQ/KAK) and ExcelVite, Malaysia. In addition, the use of the i2k Retina® software was sponsored by Dual Align (NY, USA).
Publisher Copyright:
© Asian Journal of Ophthalmology.
PY - 2021/4/16
Y1 - 2021/4/16
N2 - Aim: To identify the effects of tocotrienol-rich vitamin E from palm oil (Tocovid) on diabetic retinopathy (DR) in patients with type 2 diabetes. Materials and methods: The intervention group (n = 21) received 200 mg Tocovid twice daily while the control group (n = 22) received placebo twice daily for 8 weeks. Changes in retinal photography by conventional grading and novel quantification of retinal hemorrhage were assessed. Changes in serum biomarkers advanced glycation end products (AGE) general, sRAGE (soluble receptor of AGE), Nε-CML (specific type of AGE), and cystatin C were evaluated. Results: A novel technique to quantify retinal hemorrhage had a strong positive correlation with conventional grading of DR in both eyes at baseline and at the end of the study. Eight-week supplementation of Tocovid resulted in significant reduction in retinal hemorrhage in the right eye. Liver enzymes and ALT significantly reduced. No significant changes in grade of DR, serum biomarkers, HbA1c, blood pressure, renal profile, and lipid profile were observed. Conclusions: Tocovid is a potential adjunct to current treatment of DR and fatty liver disease. A novel method of quantifying retinal hemorrhage is a potential technique for assessing disease severity of DR, particularly the early changes.
AB - Aim: To identify the effects of tocotrienol-rich vitamin E from palm oil (Tocovid) on diabetic retinopathy (DR) in patients with type 2 diabetes. Materials and methods: The intervention group (n = 21) received 200 mg Tocovid twice daily while the control group (n = 22) received placebo twice daily for 8 weeks. Changes in retinal photography by conventional grading and novel quantification of retinal hemorrhage were assessed. Changes in serum biomarkers advanced glycation end products (AGE) general, sRAGE (soluble receptor of AGE), Nε-CML (specific type of AGE), and cystatin C were evaluated. Results: A novel technique to quantify retinal hemorrhage had a strong positive correlation with conventional grading of DR in both eyes at baseline and at the end of the study. Eight-week supplementation of Tocovid resulted in significant reduction in retinal hemorrhage in the right eye. Liver enzymes and ALT significantly reduced. No significant changes in grade of DR, serum biomarkers, HbA1c, blood pressure, renal profile, and lipid profile were observed. Conclusions: Tocovid is a potential adjunct to current treatment of DR and fatty liver disease. A novel method of quantifying retinal hemorrhage is a potential technique for assessing disease severity of DR, particularly the early changes.
KW - Advanced glycation end products
KW - Carboxymethyl-lysine
KW - Diabetic retinopathy
KW - Palm oil
KW - Tocotrienol
KW - Vitamin E
UR - http://www.scopus.com/inward/record.url?scp=85105707686&partnerID=8YFLogxK
U2 - 10.35119/asjoo.v17i4.698
DO - 10.35119/asjoo.v17i4.698
M3 - Article
AN - SCOPUS:85105707686
SN - 1560-2133
VL - 17
SP - 375
EP - 399
JO - Asian Journal of Ophthalmology
JF - Asian Journal of Ophthalmology
IS - 4
ER -