TY - JOUR
T1 - To B or not to B
T2 - B cells and the Th2-type immune response to helminths
AU - Harris, Nicola
AU - Gause, William C.
PY - 2011/2/1
Y1 - 2011/2/1
N2 - Similar T helper (Th)2-type immune responses are generated against different helminth parasites, but the mechanisms that initiate Th2 immunity, and the specific immune components that mediate protection against these parasites, can vary greatly. B cells are increasingly recognized as important during the Th2-type immune response to helminths, and B cell activation might be a target for effective vaccine development. Antibody production is a function of B cells during helminth infection and understanding how polyclonal and antigen-specific antibodies contribute should provide important insights into how protective immunity develops. In addition, B cells might also contribute to the host response against helminths through antibody-independent functions including, antigen presentation, as well as regulatory and effector activity. In this review, we examine the role of B cells during Th2-type immune response to these multicellular parasites.
AB - Similar T helper (Th)2-type immune responses are generated against different helminth parasites, but the mechanisms that initiate Th2 immunity, and the specific immune components that mediate protection against these parasites, can vary greatly. B cells are increasingly recognized as important during the Th2-type immune response to helminths, and B cell activation might be a target for effective vaccine development. Antibody production is a function of B cells during helminth infection and understanding how polyclonal and antigen-specific antibodies contribute should provide important insights into how protective immunity develops. In addition, B cells might also contribute to the host response against helminths through antibody-independent functions including, antigen presentation, as well as regulatory and effector activity. In this review, we examine the role of B cells during Th2-type immune response to these multicellular parasites.
UR - https://www.scopus.com/pages/publications/79751527363
U2 - 10.1016/j.it.2010.11.005
DO - 10.1016/j.it.2010.11.005
M3 - Review Article
C2 - 21159556
AN - SCOPUS:79751527363
SN - 1471-4906
VL - 32
SP - 80
EP - 88
JO - Trends in Immunology
JF - Trends in Immunology
IS - 2
ER -
