TY - JOUR
T1 - TNFR2 expression on CD25{hi}FOXP3{+} T cells induced upon TCR stimulation of CD4 T cells identifies maximal cytokine-producing effectors
AU - Govindaraj, Chindu
AU - Scalzo-Inguanti, Karen
AU - Scholzen, Anja
AU - Li, Shuo
AU - Plebanski, Magdalena
PY - 2013
Y1 - 2013
N2 - phenotype FOXP3+CTLA4+CD127lo/-, but produce effector and immunoregulatory cytokines including IL-2, IL-10, and IFN-g. These induced CD25hiTNFR2+ T cells do not suppress target cell proliferation, but enhance it instead. Thus the CD25hiTNFR2+ phenotype induced rapidly following CD3/28 cross linking of CD4 T cells identifies cells with maximal proliferative and effector cytokine-producing capability. The in vivo counterpart of this cell population may play an important role in immune response initiation. ? 2013 Govindaraj, Scalzo-Inguanti, Scholzen, Li and Plebanski.
AB - phenotype FOXP3+CTLA4+CD127lo/-, but produce effector and immunoregulatory cytokines including IL-2, IL-10, and IFN-g. These induced CD25hiTNFR2+ T cells do not suppress target cell proliferation, but enhance it instead. Thus the CD25hiTNFR2+ phenotype induced rapidly following CD3/28 cross linking of CD4 T cells identifies cells with maximal proliferative and effector cytokine-producing capability. The in vivo counterpart of this cell population may play an important role in immune response initiation. ? 2013 Govindaraj, Scalzo-Inguanti, Scholzen, Li and Plebanski.
UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3734366/pdf/fimmu-04-00233.pdf
U2 - 10.3389/fimmu.2013.00233
DO - 10.3389/fimmu.2013.00233
M3 - Article
SN - 1664-3224
VL - 4
SP - 1
EP - 8
JO - Frontiers in Immunology
JF - Frontiers in Immunology
IS - Art ID: 233
ER -