TNFR2 expression on CD25{hi}FOXP3{+} T cells induced upon TCR stimulation of CD4 T cells identifies maximal cytokine-producing effectors

Chindu Govindaraj, Karen Scalzo-Inguanti, Anja Scholzen, Shuo Li, Magdalena Plebanski

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18 Citations (Scopus)

Abstract

phenotype FOXP3+CTLA4+CD127lo/-, but produce effector and immunoregulatory cytokines including IL-2, IL-10, and IFN-g. These induced CD25hiTNFR2+ T cells do not suppress target cell proliferation, but enhance it instead. Thus the CD25hiTNFR2+ phenotype induced rapidly following CD3/28 cross linking of CD4 T cells identifies cells with maximal proliferative and effector cytokine-producing capability. The in vivo counterpart of this cell population may play an important role in immune response initiation. ? 2013 Govindaraj, Scalzo-Inguanti, Scholzen, Li and Plebanski.
Original languageEnglish
Pages (from-to)1 - 8
Number of pages8
JournalFrontiers in Immunology
Volume4
Issue numberArt ID: 233
DOIs
Publication statusPublished - 2013

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