TNF-R1 as a first trimester marker for prediction of pre-eclampsia

Sammya Bezerra Maia e Holanda Moura, Felicity Park, Padma Murthi, Wellington P. Martins, Stefan C. Kane, Paul Williams, Jonathan Hyett, Fabrício da Silva Costa

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Objective: To examine whether the maternal serum concentration of the soluble receptor-1 of tumor necrosis factor-α (TNF-R1) at 11-13 + 6 weeks of gestation is a predictor of development of pre-eclampsia (PE).Methods: This is a nested case-control study in which the concentration of TNF-R1 at 11 + 0 to 13 + 6 weeks was measured in 426 pregnant women in the first trimester. TNF-R1 values were expressed as multiples of the median (MoM) adjusted for maternal factors. The distributions of log TNF-R1 MoM in the control group and hypertensive disorders (early-PE [ePE], late-PE [lPE] and gestational hypertension [GH]) groups were compared. Logistic regression analysis was used to determine whether maternal factors, TNF-R1 or their combination make a significant contribution to the prediction of PE. Screening performance was determined by analysis of receiver-operating characteristics curves.Results: Median concentration of TNF-R1 (ng/ml) was higher in ePE (2.62 ± 0.67), lPE (2.12 ± 0.56) and GH (2.19 ± 0.45) compared to controls (2.04 ± 0.42), p = 0.001. Logistic regression analysis demonstrated that the addition of TNFR-1 to maternal factors did not make a significant contribution to the prediction of PE.Conclusions: The maternal serum TNF-R1 concentration at 11-13 + 6 weeks of gestation was increased in pregnancies which developed hypertensive disorders, however, the addition of TNFR-1 did not improve the detection rate of these conditions compared with maternal factors alone.

Original languageEnglish
Pages (from-to)897-903
Number of pages7
JournalThe Journal of Maternal-Fetal and Neonatal Medicine
Issue number6
Publication statusPublished - 18 Mar 2016
Externally publishedYes


  • Biomarkers
  • Hypertension
  • Obstetrics
  • Pregnancy
  • Pregnancy-induced
  • Screening

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