TNF-alpha in the locomotor system beyond joints: high degree of involvement in myositis in a rabbit model

Sture Forsgren, Lina Renstrom, Craig Purdam, James Edmund Gaida

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Abstract

The aim was to investigate the patterns of TNF-alpha expression in the developing myositis and to evaluate the usefulness of this myositis model for further TNF-alpha research. Human rheumatoid arthritis (RA) synovial tissue was examined as a reference. TNF-alpha immunoexpression and TNF-alpha mRNA, visualized via in situ hybridization, were detected in cells in the inflammatory infiltrates of the affected muscle (soleus muscle). Coexistence of TNF-alpha and CD68 immunoreactions was noted, suggesting that the TNF-alpha reactive cells are macrophages. Expression of TNF-alpha mRNA was also noted in muscle fibers and blood vessel walls in areas with inflammation. These findings demonstrate that TNF-alpha is highly involved in the myositis process. The model can be used in further studies evaluating the importance of TNF-alpha in developing myositi
Original languageEnglish
Pages (from-to)1 - 11
Number of pages11
JournalInternational Journal of Rheumatology
Volume2012
Issue number(Article ID 637452)
DOIs
Publication statusPublished - 2012

Cite this

Forsgren, Sture ; Renstrom, Lina ; Purdam, Craig ; Gaida, James Edmund. / TNF-alpha in the locomotor system beyond joints: high degree of involvement in myositis in a rabbit model. In: International Journal of Rheumatology. 2012 ; Vol. 2012, No. (Article ID 637452). pp. 1 - 11.
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TNF-alpha in the locomotor system beyond joints: high degree of involvement in myositis in a rabbit model. / Forsgren, Sture; Renstrom, Lina; Purdam, Craig; Gaida, James Edmund.

In: International Journal of Rheumatology, Vol. 2012, No. (Article ID 637452), 2012, p. 1 - 11.

Research output: Contribution to journalArticleResearchpeer-review

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AB - The aim was to investigate the patterns of TNF-alpha expression in the developing myositis and to evaluate the usefulness of this myositis model for further TNF-alpha research. Human rheumatoid arthritis (RA) synovial tissue was examined as a reference. TNF-alpha immunoexpression and TNF-alpha mRNA, visualized via in situ hybridization, were detected in cells in the inflammatory infiltrates of the affected muscle (soleus muscle). Coexistence of TNF-alpha and CD68 immunoreactions was noted, suggesting that the TNF-alpha reactive cells are macrophages. Expression of TNF-alpha mRNA was also noted in muscle fibers and blood vessel walls in areas with inflammation. These findings demonstrate that TNF-alpha is highly involved in the myositis process. The model can be used in further studies evaluating the importance of TNF-alpha in developing myositi

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