Abstract
Toll-like receptors (TLRs) are one of the best characterised families of pattern recognition receptors (PRRs) and play a critical role in the host defence to infection. Accumulating evidence indicates that TLRs also participate in maintaining tissue homeostasis by controlling inflammation and tissue repair, as well as promoting antitumour effects via activation and modulation of adaptive immune responses. TLR agonists have successfully been exploited to ameliorate the efficacy of various cancer therapies. In this chapter, we will discuss the rationales of using TLR agonists as adjuvants to cancer treatments and summarise the recent findings of preclinical and clinical studies of TLR agonist-based cancer therapies.
| Original language | English |
|---|---|
| Title of host publication | Advances in Experimental Medicine and Biology |
| Editors | Irun R. Cohen, Abel Lajtha, John D. Lambris, Rodolfo Paoletti |
| Place of Publication | Gateway East Singapore |
| Publisher | Springer |
| Pages | 195-212 |
| Number of pages | 18 |
| Volume | 1024 |
| ISBN (Electronic) | 978-981-10-5987-2 |
| ISBN (Print) | 978-981-10-5986-5 |
| DOIs | |
| Publication status | Published - 2017 |
Publication series
| Name | Advances in Experimental Medicine and Biology |
|---|---|
| Volume | 1024 |
| ISSN (Print) | 0065-2598 |
| ISSN (Electronic) | 2214-8019 |
Keywords
- Adjuvant
- Agonist
- Clinical trial
- Toll-like receptor
Cite this
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TLR agonists as adjuvants for cancer vaccines. / Li, Ji Kun; Balic, Jesse J.; Yu, Liang; Jenkins, Brendan.
Advances in Experimental Medicine and Biology. ed. / Irun R. Cohen; Abel Lajtha; John D. Lambris; Rodolfo Paoletti. Vol. 1024 Gateway East Singapore : Springer, 2017. p. 195-212 (Advances in Experimental Medicine and Biology; Vol. 1024).Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review
TY - CHAP
T1 - TLR agonists as adjuvants for cancer vaccines
AU - Li, Ji Kun
AU - Balic, Jesse J.
AU - Yu, Liang
AU - Jenkins, Brendan
PY - 2017
Y1 - 2017
N2 - Toll-like receptors (TLRs) are one of the best characterised families of pattern recognition receptors (PRRs) and play a critical role in the host defence to infection. Accumulating evidence indicates that TLRs also participate in maintaining tissue homeostasis by controlling inflammation and tissue repair, as well as promoting antitumour effects via activation and modulation of adaptive immune responses. TLR agonists have successfully been exploited to ameliorate the efficacy of various cancer therapies. In this chapter, we will discuss the rationales of using TLR agonists as adjuvants to cancer treatments and summarise the recent findings of preclinical and clinical studies of TLR agonist-based cancer therapies.
AB - Toll-like receptors (TLRs) are one of the best characterised families of pattern recognition receptors (PRRs) and play a critical role in the host defence to infection. Accumulating evidence indicates that TLRs also participate in maintaining tissue homeostasis by controlling inflammation and tissue repair, as well as promoting antitumour effects via activation and modulation of adaptive immune responses. TLR agonists have successfully been exploited to ameliorate the efficacy of various cancer therapies. In this chapter, we will discuss the rationales of using TLR agonists as adjuvants to cancer treatments and summarise the recent findings of preclinical and clinical studies of TLR agonist-based cancer therapies.
KW - Adjuvant
KW - Agonist
KW - Clinical trial
KW - Toll-like receptor
UR - http://www.scopus.com/inward/record.url?scp=85029668940&partnerID=8YFLogxK
U2 - 10.1007/978-981-10-5987-2_9
DO - 10.1007/978-981-10-5987-2_9
M3 - Chapter (Book)
SN - 978-981-10-5986-5
VL - 1024
T3 - Advances in Experimental Medicine and Biology
SP - 195
EP - 212
BT - Advances in Experimental Medicine and Biology
A2 - Cohen, Irun R.
A2 - Lajtha, Abel
A2 - Lambris, John D.
A2 - Paoletti, Rodolfo
PB - Springer
CY - Gateway East Singapore
ER -