Tissue Location Drives the Metabolic Re-Profiling of Macrophages

Tiffany Bouchery; Gillian Coakley; Nicola Harris

doi:10.20900/immunometab20200007

Tissue Location Drives the Metabolic Re-Profiling of Macrophages

Tiffany Bouchery, Gillian Coakley, Nicola Harris

Immunology Alfred Hospital

Research output: Contribution to journal › Review Article › Research › peer-review

Abstract

That metabolic phenotype can dictate the function of macrophages has been widely demonstrated in vitro, however in vivo relevance of these findings has been lacking. Sverdberg et al., observe that the in vivo microenvironment shapes the ability of macrophages to utilize glucose and thus affects their responsiveness to stimuli.

Original language	English
Article number	e200007
Number of pages	8
Journal	Immunometabolism
Volume	2
Issue number	1
DOIs	https://doi.org/10.20900/immunometab20200007
Publication status	Published - Jan 2020

Keywords

airways
glycolysis
IL-4
macrophages
metabolism
niche

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.20900/immunometab20200007Licence: CC BY

Cite this

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title = "Tissue Location Drives the Metabolic Re-Profiling of Macrophages",

abstract = "That metabolic phenotype can dictate the function of macrophages has been widely demonstrated in vitro, however in vivo relevance of these findings has been lacking. Sverdberg et al., observe that the in vivo microenvironment shapes the ability of macrophages to utilize glucose and thus affects their responsiveness to stimuli.",

keywords = "airways, glycolysis, IL-4, macrophages, metabolism, niche",

author = "Tiffany Bouchery and Gillian Coakley and Nicola Harris",

note = "Funding Information: N.L.H. is supported by a National Health and Medical Research Council (NHMRC) of Australia SRF-B fellowship. Publisher Copyright: Copyright {\textcopyright} 2020 by the author(s).",

year = "2020",

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language = "English",

volume = "2",

journal = "Immunometabolism",

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AU - Bouchery, Tiffany

AU - Coakley, Gillian

AU - Harris, Nicola

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Y1 - 2020/1

N2 - That metabolic phenotype can dictate the function of macrophages has been widely demonstrated in vitro, however in vivo relevance of these findings has been lacking. Sverdberg et al., observe that the in vivo microenvironment shapes the ability of macrophages to utilize glucose and thus affects their responsiveness to stimuli.

AB - That metabolic phenotype can dictate the function of macrophages has been widely demonstrated in vitro, however in vivo relevance of these findings has been lacking. Sverdberg et al., observe that the in vivo microenvironment shapes the ability of macrophages to utilize glucose and thus affects their responsiveness to stimuli.

KW - airways

KW - glycolysis

KW - IL-4

KW - macrophages

KW - metabolism

KW - niche

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U2 - 10.20900/immunometab20200007

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M3 - Review Article

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Tissue Location Drives the Metabolic Re-Profiling of Macrophages

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Type 2 immunity: a regulator of physiology, tissue repair and metabolism

Cite this

Tissue Location Drives the Metabolic Re-Profiling of Macrophages

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Projects

Type 2 immunity: a regulator of physiology, tissue repair and metabolism

Cite this