@article{60ae15e905004936a4f5fca5185db219,
title = "Timing of whole genome duplication is associated with tumor-specific MHC-II depletion in serous ovarian cancer",
abstract = "Whole genome duplication is frequently observed in cancer, and its prevalence in our prior analysis of end-stage, homologous recombination deficient high grade serous ovarian cancer (almost 80\% of samples) supports the notion that whole genome duplication provides a fitness advantage under the selection pressure of therapy. Here, we therefore aim to identify potential therapeutic vulnerabilities in primary high grade serous ovarian cancer with whole genome duplication by assessing differentially expressed genes and pathways in 79 samples. We observe that MHC-II expression is lowest in tumors which have acquired whole genome duplication early in tumor evolution, and further demonstrate that reduced MHC-II expression occurs in subsets of tumor cells rather than in canonical antigen-presenting cells. Early whole genome duplication is also associated with worse patient survival outcomes. Our results suggest an association between the timing of whole genome duplication, MHC-II expression and clinical outcome in high grade serous ovarian cancer that warrants further investigation for therapeutic targeting.",
author = "Burdett, \{Nikki L.\} and Willis, \{Madelynne O.\} and Ahwan Pandey and Laura Twomey and Sara Alaei and G. Chenevix-Trench and A. Green and P. Webb and A. DeFazio and D. Gertig and N. Traficante and S. Fereday and S. Moore and J. Hung and K. Harrap and T. Sadkowsky and N. Pandeya and L. Bowes and L. Galletta and D. Giles and J. Hendley and K. Alsop and B. Alexander and P. Ashover and S. Brown and T. Corrish and L. Green and L. Jackman and K. Ferguson and K. Martin and A. Martyn and B. Ranieri and M. Malt and Chiew, \{Y. E.\} and A. Stenlake and H. Sullivan and A. Mellon and R. Robertson and Bergh, \{T. Vanden\} and M. Jones and P. Mackenzie and J. Maidens and K. Nattress and J. White and V. Jayde and P. Mamers and T. Schmidt and H. Shirley and S. Viduka and H. Tran and S. Bilic and L. Glavinas and C. Ball and C. Young and J. Brooks and L. Mileshkin and G. Au-Yeung and K. Phillips and D. Rischin and N. Burdett and R. Delahunty and D. Garsed and S. Fox and D. Johnson and S. Lade and M. Loughrey and N. O{\textquoteright}Callaghan and W. Murray and D. Purdie and D. Whiteman and A. Proietto and S. Braye and G. Otton and C. Camaris and R. Crouch and L. Edwards and N. Hacker and D. Marsden and G. Robertson and D. Bell and S. Baron-Hay and A. Ferrier and G. Gard and D. Nevell and N. Pavlakis and S. Valmadre and B. Young and P. Beale and J. Beith and J. Carter and C. Dalrymple and R. Houghton and P. Russell and M. Davy and Oehler, \{M. K.\} and C. Hall and T. Dodd and P. Blomfield and D. Challis and R. McIntosh and A. Parker and D. Healy and T. Jobling and T. Manolitsas and J. McNealage and P. Rogers and B. Susil and E. Sumithran and I. Simpson and N. Zeps and I. Hammond and Y. Leung and A. McCartney and R. Stuart-Harris and F. Kirsten and J. Rutovitz and P. Clingan and J. Shannon and T. Bonaventura and J. Stewart and S. Begbie and A. Glasgow and M. Friedlander and M. Links and J. Grygiel and J. Hill and A. Brand and K. Byth and P. Harnett and G. Wain and R. Jaworski and R. Sharma and B. Ward and D. Papadimos and A. Crandon and M. Cummings and K. Horwood and A. Obermair and L. Perrin and D. Wyld and J. Nicklin and T. Healy and K. Pittman and D. Henderson and J. Miller and J. Pierdes and B. Brown and R. Rome and D. Allen and P. Grant and S. Hyde and R. Laurie and M. Robbie and P. Waring and V. Billson and J. Pyman and D. Neesham and M. Quinn and C. Underhill and R. Bell and Ng, \{L. F.\} and R. Blum and V. Ganju and M. Buck and I. Haviv and Bowtell, \{David D.L.\} and Christie, \{Elizabeth L.\} and \{Australian Ovarian Cancer Study Group (AOCS)\}",
note = "Publisher Copyright: {\textcopyright} The Author(s) 2024.",
year = "2024",
month = dec,
doi = "10.1038/s41467-024-50137-y",
language = "English",
volume = "15",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",
}
SDG 3 Good Health and Well-being