Abstract
Significant tension surrounds the application of antibiotics in suspected infection. Guidelines stress the importance of early empirical broad-spectrum therapy, with select observational data suggesting inferior outcomes when this is delayed. In contrast, microbiological resistance is an ever increasing global problem, with many advocating for a more restricted, culture-driven approach to antibiotic prescription. Controlled trial data are urgently needed, although many clinicians would find withholding of antibiotic therapy unethical. A trial of prehospital antibiotic administration (by paramedics) in patients with suspected sepsis would therefore provide crucial data, and go a long way to determining whether earlier empirical therapy does actually improve outcomes.
| Original language | English |
|---|---|
| Pages (from-to) | 270-272 |
| Number of pages | 3 |
| Journal | EMA - Emergency Medicine Australasia |
| Volume | 30 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Apr 2018 |
Keywords
- Antibiotics
- Emergency medicine
- Prehospital care
- Sepsis
Cite this
}
Timing of antibiotics in the management of community-acquired sepsis : Can a randomised controlled trial of prehospital therapy provide answers? / Udy, Andrew A.; Smith, Karen; Bernard, Stephen.
In: EMA - Emergency Medicine Australasia, Vol. 30, No. 2, 04.2018, p. 270-272.Research output: Contribution to journal › Article › Other › peer-review
TY - JOUR
T1 - Timing of antibiotics in the management of community-acquired sepsis
T2 - Can a randomised controlled trial of prehospital therapy provide answers?
AU - Udy, Andrew A.
AU - Smith, Karen
AU - Bernard, Stephen
PY - 2018/4
Y1 - 2018/4
N2 - Significant tension surrounds the application of antibiotics in suspected infection. Guidelines stress the importance of early empirical broad-spectrum therapy, with select observational data suggesting inferior outcomes when this is delayed. In contrast, microbiological resistance is an ever increasing global problem, with many advocating for a more restricted, culture-driven approach to antibiotic prescription. Controlled trial data are urgently needed, although many clinicians would find withholding of antibiotic therapy unethical. A trial of prehospital antibiotic administration (by paramedics) in patients with suspected sepsis would therefore provide crucial data, and go a long way to determining whether earlier empirical therapy does actually improve outcomes.
AB - Significant tension surrounds the application of antibiotics in suspected infection. Guidelines stress the importance of early empirical broad-spectrum therapy, with select observational data suggesting inferior outcomes when this is delayed. In contrast, microbiological resistance is an ever increasing global problem, with many advocating for a more restricted, culture-driven approach to antibiotic prescription. Controlled trial data are urgently needed, although many clinicians would find withholding of antibiotic therapy unethical. A trial of prehospital antibiotic administration (by paramedics) in patients with suspected sepsis would therefore provide crucial data, and go a long way to determining whether earlier empirical therapy does actually improve outcomes.
KW - Antibiotics
KW - Emergency medicine
KW - Prehospital care
KW - Sepsis
UR - http://www.scopus.com/inward/record.url?scp=85034023911&partnerID=8YFLogxK
U2 - 10.1111/1742-6723.12908
DO - 10.1111/1742-6723.12908
M3 - Article
VL - 30
SP - 270
EP - 272
JO - EMA - Emergency Medicine Australasia
JF - EMA - Emergency Medicine Australasia
SN - 1742-6731
IS - 2
ER -