Research output per year
Research output per year
Yeong Shiong Chiew, Sarah F. Poole, Daniel P. Redmond, Erwin J. Van Drunen, Nor Salwa Damanhuri, Christopher Pretty, Paul D. Docherty, Bernard Lambermont, Geoffrey M. Shaw, Thomas Desaive, J. Geoffrey Chase
Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Other
Respiratory mechanics models can be used to optimise patient-specific mechanical ventilation (MV), but are limited to fully sedated MV patients who are not spontaneously breathing. This research presents a non-invasive model-based method to determine respiratory mechanics of spontaneously breathing MV patients. Patient-specific respiratory mechanics of 22 spontaneously breathing patients are described using a single compartment lung model with time-varying elastance (Edrs). The normalised Edrs trajectories and the area under the curves (AUCEdrs) are calculated using clinical data from 22 patients ventilated using pressure support (PS) and neurally adjusted ventilatory assist (NAVA). Edrs trajectories are also compared between ventilation modes. Edrs for PS ventilation were significantly higher compared to NAVA (p < 0.05). Edrs trajectories were more variable during NAVA than PS (p < 0.05). 20 of 22 patients had AUCEdrs > 25 cmH2Os/l. The AUCEdrs is a surrogate of elastance, and thus can be used as a respiratory failure severity indicator. This non-invasive model-based approach captures unique dynamic respiratory mechanics for spontaneously breathing patients during PS and NAVA. The model is fully general and is applicable to both fully controlled and partially assisted MV modes, with the resulting potential to standardise treatment for all MV patients.
Original language | English |
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Title of host publication | 19th IFAC World Congress IFAC 2014, Proceedings |
Editors | Edward Boje, Xiaohua Xia |
Publisher | Elsevier - International Federation of Automatic Control (IFAC) |
Pages | 5659-5664 |
Number of pages | 6 |
ISBN (Electronic) | 9783902823625 |
DOIs | |
Publication status | Published - 2014 |
Externally published | Yes |
Event | International Federation of Automatic Control World Congress 2014 - Cape Town International Convention Centre, Cape Town, South Africa Duration: 24 Aug 2014 → 29 Aug 2014 Conference number: 19th http://www.ifac2014.org/ |
Name | IFAC Proceedings Volumes (IFAC-PapersOnline) |
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Volume | 19 |
ISSN (Print) | 1474-6670 |
Conference | International Federation of Automatic Control World Congress 2014 |
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Abbreviated title | IFAC 2014 |
Country/Territory | South Africa |
City | Cape Town |
Period | 24/08/14 → 29/08/14 |
Internet address |
Research output: Contribution to journal › Article › Research › peer-review