Time to death and mast cell degranulation in fatal asthma

John G Elliot, Michael John Abramson, Olaf Heino Drummer, E Haydn Walters, Alan L James

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Abstract

This study assessed whether the strength of an exacerbating stimulus might explain the consistent dichotomy in duration of fatal asthma attacks. Although total mast cell numbers were similar, the ratio of degranulated to intact mast cells and proportional muscle shortening were increased in short-duration compared with long-duration cases of fatal asthma. This is consistent with a stronger exacerbating stimulus.
Original languageEnglish
Pages (from-to)808 - 813
Number of pages6
JournalRespirology
Volume14
Issue number6
Publication statusPublished - 2009

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