TY - JOUR
T1 - Time-Resolved Terbium-Based Probe for the Detection of Zinc(II) Ions
T2 - Investigation of the Formation of a Luminescent Ternary Complex
AU - Winnett, Matthew R.
AU - Mini, Parvathy
AU - Grace, Michael R.
AU - Tuck, Kellie L.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Because of their unique photochemical and photophysical properties, luminescent lanthanide-based complexes have long captivated chemists. In recent years, the number of reports of luminescent lanthanide complex-based probes for monitoring of biological and environmental processes has dramatically increased, namely, because of their selectivity for particular analytes, lower limits of detection, and the fact that they allow monitoring of analytes in real time. Lanthanide-based probes need to be paired with an appropriate antenna/sensitizer to allow maximum energy transfer, with the antenna typically covalently attached to the stable lanthanide chelate. We have recently investigated "dark" lanthanide-based probes where the sensitizer is not covalently linked to the lanthanide chelate. Herein we report the use of a luminescent lanthanide-based probe system for the detection of Zn2+ ions based on the formation of a ternary complex between a "dark" terbium complex, lumazine, and Zn2+. The terbium(III)-based probe incorporates a 1,4,7,10-tetraazacyclododecane-1,4,7,10-triacetic acid macrocyclic chelator covalently attached to a cyclen moiety, which is the Zn2+ ion binding group. In the presence of Zn2+ ions and lumazine (a strongly UV-absorbing sensitizer), a 1:1:1 ternary complex forms. The resulting complex is highly luminescent and selective for Zn2+ ions over other cations of environmental significance. Furthermore, with a limit of detection of 1.2 μM, this probe can detect the level of chronic zinc(II) concentrations denoted by the U.S. Environmental Protection Agency.
AB - Because of their unique photochemical and photophysical properties, luminescent lanthanide-based complexes have long captivated chemists. In recent years, the number of reports of luminescent lanthanide complex-based probes for monitoring of biological and environmental processes has dramatically increased, namely, because of their selectivity for particular analytes, lower limits of detection, and the fact that they allow monitoring of analytes in real time. Lanthanide-based probes need to be paired with an appropriate antenna/sensitizer to allow maximum energy transfer, with the antenna typically covalently attached to the stable lanthanide chelate. We have recently investigated "dark" lanthanide-based probes where the sensitizer is not covalently linked to the lanthanide chelate. Herein we report the use of a luminescent lanthanide-based probe system for the detection of Zn2+ ions based on the formation of a ternary complex between a "dark" terbium complex, lumazine, and Zn2+. The terbium(III)-based probe incorporates a 1,4,7,10-tetraazacyclododecane-1,4,7,10-triacetic acid macrocyclic chelator covalently attached to a cyclen moiety, which is the Zn2+ ion binding group. In the presence of Zn2+ ions and lumazine (a strongly UV-absorbing sensitizer), a 1:1:1 ternary complex forms. The resulting complex is highly luminescent and selective for Zn2+ ions over other cations of environmental significance. Furthermore, with a limit of detection of 1.2 μM, this probe can detect the level of chronic zinc(II) concentrations denoted by the U.S. Environmental Protection Agency.
UR - http://www.scopus.com/inward/record.url?scp=85072575688&partnerID=8YFLogxK
U2 - 10.1021/acs.inorgchem.9b01771
DO - 10.1021/acs.inorgchem.9b01771
M3 - Article
AN - SCOPUS:85072575688
SN - 0020-1669
VL - 59
SP - 118
EP - 127
JO - Inorganic Chemistry
JF - Inorganic Chemistry
IS - 1
ER -