Time from first symptom onset to the final diagnosis of multiple myeloma (MM)–possible risks and future solutions: retrospective and prospective ‘Deutsche Studiengruppe MM’ (DSMM) and ‘European Myeloma Network’ (EMN) analysis*

Giulia Graziani, Georg W. Herget, Gabriele Ihorst, Mara Zeissig, Aristeidis Chaidos, Holger W. Auner, Justus Duyster, Ralph Wäsch, Monika Engelhardt

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4 Citations (Scopus)


Multiple myeloma (MM) often presents with unspecific symptoms and is challenging to diagnose. We performed this DSMM/EMN-analysis via test-(retro-) and validation (prospective) study to determine the time interval from the onset of first symptoms to the diagnosis of MM. The retrospective and prospective analyses were performed in 101 and 176 patients, respectively. The median time from first symptoms to the MM diagnosis in both cohorts was 4 and 6 months, respectively. Frequencies of MM-related pathologic bone fractures, renal, and infectious complications at diagnosis occurred in 41%, 35%, and 16% of patients, respectively. Our MM-questionnaire determined that 39% of patients were dissatisfied with the diagnostic process. PFS and OS proved insignificantly different with shorter (≤6) and longer (>6 months) latency periods. In conclusion, our in depth studies demonstrate that delays in diagnosis do not decrease PFS or OS, but induce MM-related complications and influence patients’ satisfaction with their medical care.

Original languageEnglish
Pages (from-to)875-886
Number of pages12
JournalLeukemia and Lymphoma
Issue number4
Publication statusPublished - 20 Mar 2020
Externally publishedYes


  • complication avoidance
  • early diagnosis
  • health services research
  • Multiple myeloma
  • time to diagnosis

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