Thymus Microenvironment: Maintenance, Ageing and Strategies for Thymus Regeneration Following Damage

Abdulaziz Abdulmohsin M Alsharif, Ann P. Chidgey

Research output: Chapter in Book/Report/Conference proceedingEncyclopaedia / Dictionary EntryOtherpeer-review

Abstract

The thymus is the major site of T-lymphocyte production. Nonlymphoid elements, referred to as the thymic stroma, create the thymic microenvironment required to govern differentiation, maturation and tolerance induction of haematopoietic precursors into immune-competent, nonautoreactive T cells. Thymic epithelial cells (TECs) are integral to thymopoiesis but are affected by ageing. From the onset of puberty, a proportional imbalance of TEC subpopulations coincides with a dramatic numerical loss of developing T cells. By middle-age numerical loss of TECs accompanies further loss of thymocytes. Ongoing functional impediment of bipotent thymic epithelial progenitor cells (TEPC) has been proposed as one possible underlying cause and is more apparent in males. As such, endogenous recovery following thymic damage, such as from chemotherapy, in middle-aged males relies heavily on proliferation of residual immature and mature TECs than through homeostatic differentiation of bipotent TEPC evident in middle-aged females. Various strategies have been proposed to enhance thymus recovery following cytoablative therapies; however, thus far, temporary suppression of sex hormone production appears to have the most wide-ranging impact on enhancing mature TEC replenishment and thymopoiesis.
Original languageEnglish
Title of host publicationeLS
Subtitle of host publicationEncyclopedia of Life Sciences
Place of PublicationUnited Kingdom
PublisherJohn Wiley & Sons
Pages1-17
Number of pages17
Volume3
ISBN (Electronic)9780470015902
DOIs
Publication statusPublished - 27 Sept 2022

Keywords

  • thymus
  • T cells
  • Thymic epithelial cells
  • immune ageing
  • T cell regeneration
  • Thymus regeneration
  • Immune dysfunction

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