Thymic involution and immune reconstitution

Heather E Lynch, Gabrielle L Goldberg, Ann Patricia Chidgey, Marcel R M van den Brink, Richard Lennox Boyd, Gregory D Sempowski

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    301 Citations (Scopus)

    Abstract

    Chronic thymus involution associated with aging results in less efficient T-cell development and decreased emigration of naive T cells to the periphery. Thymic decline in the aged is linked to increased morbidity and mortality in a wide range of clinical settings. Negative consequences of these effects on global health make it of paramount importance to understand the mechanisms driving thymic involution and homeostatic processes across the lifespan. There is growing evidence that thymus tissue is plastic and that the involution process might be therapeutically halted or reversed. We present here progress on the exploitation of thymosuppressive and thymostimulatory pathways using factors such as keratinocyte growth factor, interleukin 7 or sex steroid ablation for therapeutic thymus restoration and peripheral immune reconstitution in adults.
    Original languageEnglish
    Pages (from-to)366 - 373
    Number of pages8
    JournalTrends in Immunology
    Volume30
    Issue number7
    DOIs
    Publication statusPublished - 2009

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