Thrombotic and cardiovascular risks in type two diabetes; Role of platelet hyperactivity

Almottesembellah Gaiz, Sapha Mosawy, Natalie Colson, Indu Singh

Research output: Contribution to journalReview ArticleResearchpeer-review

23 Citations (Scopus)

Abstract

One of the most commonly identified chronic illnesses in many countries is type 2 diabetes mellitus (T2DM). T2DM denotes an independent risk factor for cardiovascular disease (CVD). Heart disease is one of the causes of mortality in patients with diabetes, mainly due to the macrovascular complications. One of these macrovascular complications in diabetes is atherosclerosis, which involves a complicated pathophysiological process. Besides hyperglycemia, oxidative stress plays a significant role in the pathogenesis of diabetes and its associated risk of CVD. There are many other factors including molecular, metabolic, lipid, fibrinolytic, and platelet function disorders precipitate to thrombotic and CVD risks in T2DM. Also, Platelets have an increased response to procoagulants in patients with diabetes. Platelet hyperactivity, in the presence of oxidative stress, has a major effect on the progression of thrombotic and CVD events. This review will discuss the impact of the above factors and the potential effects of platelet hyperactivity on thrombotic and cardiovascular risks.

Original languageEnglish
Pages (from-to)679-686
Number of pages8
JournalBiomedicine & Pharmacotherapy
Volume94
DOIs
Publication statusPublished - Oct 2017
Externally publishedYes

Keywords

  • CVD
  • Diabetes
  • Hyperactive platelets
  • Oxidative stress
  • Thrombosis

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