Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis

Elisa D'Alessandro; Christian Becker; Wolfgang Bergmeier; Christoph Bode; Joshua H. Bourne; Helena Brown; Harry R. Buller; Arina J. Ten Cate-Hoek; Vincent Ten Cate; Yvonne J.M. Van Cauteren; Yam F.H. Cheung; Audrey Cleuren; Danielle Coenen; Harry J.G.M. Crijns; Ilaria De Simone; Sophie C. Dolleman; Christine Espinola Klein; Delia I. Fernandez; Lianne Granneman; Arnoud Van T Hof; Peter Henke; Yvonne M.C. Henskens; Jingnan Huang; Lisa K. Jennings; Natalie Jooss; Mieke Karel; Danique Van Den Kerkhof; Frederik A. Klok; Bram Kremers; Bernhard Lämmle; Avi Leader; Annika Lundstrom; Nigel Mackman; Pier M. Mannucci; Zahra Maqsood; Paola E.J. Van Der Meijden; Marc Van Moorsel; Luis A. Moran; John Morser; Manouk Van Mourik; Stefano Navarro; Raluca A.I. Neagoe; Renske H. Olie; Pauline Van Paridon; Jens Posma; Isabella Provenzale; Pieter H. Reitsma; Billy Scaf; Leon Schurgers; Jaap Seelig; Agneta Siegbahn; Bob Siegerink; Oliver Soehnlein; Eva Maria Soriano; Marcin A. Sowa; Henri M.H. Spronk; Robert F. Storey; Chukiat Tantiwong; Alicia Veninga; Xueqing Wang; Steve P. Watson; Jeff Weitz; Sacha S. Zeerleder; Hugo Ten Cate

doi:10.1055/s-0040-1708035

Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis

Elisa D'Alessandro, Christian Becker, Wolfgang Bergmeier, Christoph Bode, Joshua H. Bourne, Helena Brown, Harry R. Buller, Arina J. Ten Cate-Hoek, Vincent Ten Cate, Yvonne J.M. Van Cauteren, Yam F.H. Cheung, Audrey Cleuren, Danielle Coenen, Harry J.G.M. Crijns, Ilaria De Simone, Sophie C. Dolleman, Christine Espinola Klein, Delia I. Fernandez, Lianne Granneman, Arnoud Van T HofPeter Henke, Yvonne M.C. Henskens, Jingnan Huang, Lisa K. Jennings, Natalie Jooss, Mieke Karel, Danique Van Den Kerkhof, Frederik A. Klok, Bram Kremers, Bernhard Lämmle, Avi Leader, Annika Lundstrom, Nigel Mackman, Pier M. Mannucci, Zahra Maqsood, Paola E.J. Van Der Meijden, Marc Van Moorsel, Luis A. Moran, John Morser, Manouk Van Mourik, Stefano Navarro, Raluca A.I. Neagoe, Renske H. Olie, Pauline Van Paridon, Jens Posma, Isabella Provenzale, Pieter H. Reitsma, Billy Scaf, Leon Schurgers, Jaap Seelig, Agneta Siegbahn, Bob Siegerink, Oliver Soehnlein, Eva Maria Soriano, Marcin A. Sowa, Henri M.H. Spronk, Robert F. Storey, Chukiat Tantiwong, Alicia Veninga, Xueqing Wang, Steve P. Watson, Jeff Weitz, Sacha S. Zeerleder, Hugo Ten Cate

Research output: Contribution to journal › Review Article › Other › peer-review

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Abstract

Thrombo-inflammation describes the complex interplay between blood coagulation and inflammation that plays a critical role in cardiovascular diseases. The third Maastricht Consensus Conference on Thrombosis assembled basic, translational, and clinical scientists to discuss the origin and potential consequences of thrombo-inflammation in the etiology, diagnostics, and management of patients with cardiovascular disease, including myocardial infarction, stroke, and peripheral artery disease. This article presents a state-of-the-art reflection of expert opinions and consensus recommendations regarding the following topics: (1) challenges of the endothelial cell barrier; (2) circulating cells and thrombo-inflammation, focused on platelets, neutrophils, and neutrophil extracellular traps; (3) procoagulant mechanisms; (4) arterial vascular changes in atherogenesis; attenuating atherosclerosis and ischemia/reperfusion injury; (5) management of patients with arterial vascular disease; and (6) pathogenesis of venous thrombosis and late consequences of venous thromboembolism.

Original language	English
Pages (from-to)	538-564
Number of pages	27
Journal	Thrombosis and Haemostasis
Volume	120
Issue number	4
DOIs	https://doi.org/10.1055/s-0040-1708035
Publication status	Published - Apr 2020
Externally published	Yes

Keywords

Coagulation
Inflammation
Myocardial infarction
Platelets
Pulmonary embolism
Stroke
Thrombosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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D'Alessandro, E., Becker, C., Bergmeier, W., Bode, C., Bourne, J. H., Brown, H., Buller, H. R., Ten Cate-Hoek, A. J., Ten Cate, V., Van Cauteren, Y. J. M., Cheung, Y. F. H., Cleuren, A., Coenen, D., Crijns, H. J. G. M., De Simone, I., Dolleman, S. C., Klein, C. E., Fernandez, D. I., Granneman, L., ... Ten Cate, H. (2020). Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis. Thrombosis and Haemostasis, 120(4), 538-564. https://doi.org/10.1055/s-0040-1708035

@article{f472c91a03b2492cb32927629172ac54,

title = "Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis",

abstract = "Thrombo-inflammation describes the complex interplay between blood coagulation and inflammation that plays a critical role in cardiovascular diseases. The third Maastricht Consensus Conference on Thrombosis assembled basic, translational, and clinical scientists to discuss the origin and potential consequences of thrombo-inflammation in the etiology, diagnostics, and management of patients with cardiovascular disease, including myocardial infarction, stroke, and peripheral artery disease. This article presents a state-of-the-art reflection of expert opinions and consensus recommendations regarding the following topics: (1) challenges of the endothelial cell barrier; (2) circulating cells and thrombo-inflammation, focused on platelets, neutrophils, and neutrophil extracellular traps; (3) procoagulant mechanisms; (4) arterial vascular changes in atherogenesis; attenuating atherosclerosis and ischemia/reperfusion injury; (5) management of patients with arterial vascular disease; and (6) pathogenesis of venous thrombosis and late consequences of venous thromboembolism.",

keywords = "Coagulation, Inflammation, Myocardial infarction, Platelets, Pulmonary embolism, Stroke, Thrombosis",

author = "Elisa D'Alessandro and Christian Becker and Wolfgang Bergmeier and Christoph Bode and Bourne, {Joshua H.} and Helena Brown and Buller, {Harry R.} and {Ten Cate-Hoek}, {Arina J.} and {Ten Cate}, Vincent and {Van Cauteren}, {Yvonne J.M.} and Cheung, {Yam F.H.} and Audrey Cleuren and Danielle Coenen and Crijns, {Harry J.G.M.} and {De Simone}, Ilaria and Dolleman, {Sophie C.} and Klein, {Christine Espinola} and Fernandez, {Delia I.} and Lianne Granneman and {Van T Hof}, Arnoud and Peter Henke and Henskens, {Yvonne M.C.} and Jingnan Huang and Jennings, {Lisa K.} and Natalie Jooss and Mieke Karel and {Van Den Kerkhof}, Danique and Klok, {Frederik A.} and Bram Kremers and Bernhard L{\"a}mmle and Avi Leader and Annika Lundstrom and Nigel Mackman and Mannucci, {Pier M.} and Zahra Maqsood and {Van Der Meijden}, {Paola E.J.} and {Van Moorsel}, Marc and Moran, {Luis A.} and John Morser and {Van Mourik}, Manouk and Stefano Navarro and Neagoe, {Raluca A.I.} and Olie, {Renske H.} and {Van Paridon}, Pauline and Jens Posma and Isabella Provenzale and Reitsma, {Pieter H.} and Billy Scaf and Leon Schurgers and Jaap Seelig and Agneta Siegbahn and Bob Siegerink and Oliver Soehnlein and Soriano, {Eva Maria} and Sowa, {Marcin A.} and Spronk, {Henri M.H.} and Storey, {Robert F.} and Chukiat Tantiwong and Alicia Veninga and Xueqing Wang and Watson, {Steve P.} and Jeff Weitz and Zeerleder, {Sacha S.} and {Ten Cate}, Hugo",

note = "Funding Information: This project has received funding from the European Union{\textquoteright}s Horizon 2020 research and innovation program under the Marie Sk{\l}odowska-Curie grant agreement number 766118.” E.D., S.C.D., and B.S. are supported by a grant from the Netherlands Heart Foundation (CVON2014–09, RACE V, reappraisal of AF: interaction between hypercoagulability, electrical remodeling, and vascular destabilization in the progression of AF). Publisher Copyright: {\textcopyright} 2020 Georg Thieme Verlag KG Stuttgart New York.",

year = "2020",

month = apr,

doi = "10.1055/s-0040-1708035",

language = "English",

volume = "120",

pages = "538--564",

journal = "Thrombosis and Haemostasis",

issn = "0340-6245",

publisher = "Georg Thieme",

number = "4",

}

D'Alessandro, E, Becker, C, Bergmeier, W, Bode, C, Bourne, JH, Brown, H, Buller, HR, Ten Cate-Hoek, AJ, Ten Cate, V, Van Cauteren, YJM, Cheung, YFH, Cleuren, A, Coenen, D, Crijns, HJGM, De Simone, I, Dolleman, SC, Klein, CE, Fernandez, DI, Granneman, L, Van T Hof, A, Henke, P, Henskens, YMC, Huang, J, Jennings, LK, Jooss, N, Karel, M, Van Den Kerkhof, D, Klok, FA, Kremers, B, Lämmle, B, Leader, A, Lundstrom, A, Mackman, N, Mannucci, PM, Maqsood, Z, Van Der Meijden, PEJ, Van Moorsel, M, Moran, LA, Morser, J, Van Mourik, M, Navarro, S, Neagoe, RAI, Olie, RH, Van Paridon, P, Posma, J, Provenzale, I, Reitsma, PH, Scaf, B, Schurgers, L, Seelig, J, Siegbahn, A, Siegerink, B, Soehnlein, O, Soriano, EM, Sowa, MA, Spronk, HMH, Storey, RF, Tantiwong, C, Veninga, A, Wang, X, Watson, SP, Weitz, J, Zeerleder, SS & Ten Cate, H 2020, 'Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis', Thrombosis and Haemostasis, vol. 120, no. 4, pp. 538-564. https://doi.org/10.1055/s-0040-1708035

TY - JOUR

T1 - Thrombo-Inflammation in Cardiovascular Disease

T2 - An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis

AU - D'Alessandro, Elisa

AU - Becker, Christian

AU - Bergmeier, Wolfgang

AU - Bode, Christoph

AU - Bourne, Joshua H.

AU - Brown, Helena

AU - Buller, Harry R.

AU - Ten Cate-Hoek, Arina J.

AU - Ten Cate, Vincent

AU - Van Cauteren, Yvonne J.M.

AU - Cheung, Yam F.H.

AU - Cleuren, Audrey

AU - Coenen, Danielle

AU - Crijns, Harry J.G.M.

AU - De Simone, Ilaria

AU - Dolleman, Sophie C.

AU - Klein, Christine Espinola

AU - Fernandez, Delia I.

AU - Granneman, Lianne

AU - Van T Hof, Arnoud

AU - Henke, Peter

AU - Henskens, Yvonne M.C.

AU - Huang, Jingnan

AU - Jennings, Lisa K.

AU - Jooss, Natalie

AU - Karel, Mieke

AU - Van Den Kerkhof, Danique

AU - Klok, Frederik A.

AU - Kremers, Bram

AU - Lämmle, Bernhard

AU - Leader, Avi

AU - Lundstrom, Annika

AU - Mackman, Nigel

AU - Mannucci, Pier M.

AU - Maqsood, Zahra

AU - Van Der Meijden, Paola E.J.

AU - Van Moorsel, Marc

AU - Moran, Luis A.

AU - Morser, John

AU - Van Mourik, Manouk

AU - Navarro, Stefano

AU - Neagoe, Raluca A.I.

AU - Olie, Renske H.

AU - Van Paridon, Pauline

AU - Posma, Jens

AU - Provenzale, Isabella

AU - Reitsma, Pieter H.

AU - Scaf, Billy

AU - Schurgers, Leon

AU - Seelig, Jaap

AU - Siegbahn, Agneta

AU - Siegerink, Bob

AU - Soehnlein, Oliver

AU - Soriano, Eva Maria

AU - Sowa, Marcin A.

AU - Spronk, Henri M.H.

AU - Storey, Robert F.

AU - Tantiwong, Chukiat

AU - Veninga, Alicia

AU - Wang, Xueqing

AU - Watson, Steve P.

AU - Weitz, Jeff

AU - Zeerleder, Sacha S.

AU - Ten Cate, Hugo

N1 - Funding Information: This project has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement number 766118.” E.D., S.C.D., and B.S. are supported by a grant from the Netherlands Heart Foundation (CVON2014–09, RACE V, reappraisal of AF: interaction between hypercoagulability, electrical remodeling, and vascular destabilization in the progression of AF). Publisher Copyright: © 2020 Georg Thieme Verlag KG Stuttgart New York.

PY - 2020/4

Y1 - 2020/4

N2 - Thrombo-inflammation describes the complex interplay between blood coagulation and inflammation that plays a critical role in cardiovascular diseases. The third Maastricht Consensus Conference on Thrombosis assembled basic, translational, and clinical scientists to discuss the origin and potential consequences of thrombo-inflammation in the etiology, diagnostics, and management of patients with cardiovascular disease, including myocardial infarction, stroke, and peripheral artery disease. This article presents a state-of-the-art reflection of expert opinions and consensus recommendations regarding the following topics: (1) challenges of the endothelial cell barrier; (2) circulating cells and thrombo-inflammation, focused on platelets, neutrophils, and neutrophil extracellular traps; (3) procoagulant mechanisms; (4) arterial vascular changes in atherogenesis; attenuating atherosclerosis and ischemia/reperfusion injury; (5) management of patients with arterial vascular disease; and (6) pathogenesis of venous thrombosis and late consequences of venous thromboembolism.

AB - Thrombo-inflammation describes the complex interplay between blood coagulation and inflammation that plays a critical role in cardiovascular diseases. The third Maastricht Consensus Conference on Thrombosis assembled basic, translational, and clinical scientists to discuss the origin and potential consequences of thrombo-inflammation in the etiology, diagnostics, and management of patients with cardiovascular disease, including myocardial infarction, stroke, and peripheral artery disease. This article presents a state-of-the-art reflection of expert opinions and consensus recommendations regarding the following topics: (1) challenges of the endothelial cell barrier; (2) circulating cells and thrombo-inflammation, focused on platelets, neutrophils, and neutrophil extracellular traps; (3) procoagulant mechanisms; (4) arterial vascular changes in atherogenesis; attenuating atherosclerosis and ischemia/reperfusion injury; (5) management of patients with arterial vascular disease; and (6) pathogenesis of venous thrombosis and late consequences of venous thromboembolism.

KW - Coagulation

KW - Inflammation

KW - Myocardial infarction

KW - Platelets

KW - Pulmonary embolism

KW - Stroke

KW - Thrombosis

UR - http://www.scopus.com/inward/record.url?scp=85083412632&partnerID=8YFLogxK

U2 - 10.1055/s-0040-1708035

DO - 10.1055/s-0040-1708035

M3 - Review Article

C2 - 32289858

AN - SCOPUS:85083412632

SN - 0340-6245

VL - 120

SP - 538

EP - 564

JO - Thrombosis and Haemostasis

JF - Thrombosis and Haemostasis

IS - 4

ER -

Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis

Abstract

Keywords

UN SDGs

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