Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus Conference on Thrombosis

Elisa D'Alessandro, Christian Becker, Wolfgang Bergmeier, Christoph Bode, Joshua H. Bourne, Helena Brown, Harry R. Buller, Arina J. Ten Cate-Hoek, Vincent Ten Cate, Yvonne J.M. Van Cauteren, Yam F.H. Cheung, Audrey Cleuren, Danielle Coenen, Harry J.G.M. Crijns, Ilaria De Simone, Sophie C. Dolleman, Christine Espinola Klein, Delia I. Fernandez, Lianne Granneman, Arnoud Van T HofPeter Henke, Yvonne M.C. Henskens, Jingnan Huang, Lisa K. Jennings, Natalie Jooss, Mieke Karel, Danique Van Den Kerkhof, Frederik A. Klok, Bram Kremers, Bernhard Lämmle, Avi Leader, Annika Lundstrom, Nigel Mackman, Pier M. Mannucci, Zahra Maqsood, Paola E.J. Van Der Meijden, Marc Van Moorsel, Luis A. Moran, John Morser, Manouk Van Mourik, Stefano Navarro, Raluca A.I. Neagoe, Renske H. Olie, Pauline Van Paridon, Jens Posma, Isabella Provenzale, Pieter H. Reitsma, Billy Scaf, Leon Schurgers, Jaap Seelig, Agneta Siegbahn, Bob Siegerink, Oliver Soehnlein, Eva Maria Soriano, Marcin A. Sowa, Henri M.H. Spronk, Robert F. Storey, Chukiat Tantiwong, Alicia Veninga, Xueqing Wang, Steve P. Watson, Jeff Weitz, Sacha S. Zeerleder, Hugo Ten Cate

Research output: Contribution to journalReview ArticleOtherpeer-review

60 Citations (Scopus)


Thrombo-inflammation describes the complex interplay between blood coagulation and inflammation that plays a critical role in cardiovascular diseases. The third Maastricht Consensus Conference on Thrombosis assembled basic, translational, and clinical scientists to discuss the origin and potential consequences of thrombo-inflammation in the etiology, diagnostics, and management of patients with cardiovascular disease, including myocardial infarction, stroke, and peripheral artery disease. This article presents a state-of-the-art reflection of expert opinions and consensus recommendations regarding the following topics: (1) challenges of the endothelial cell barrier; (2) circulating cells and thrombo-inflammation, focused on platelets, neutrophils, and neutrophil extracellular traps; (3) procoagulant mechanisms; (4) arterial vascular changes in atherogenesis; attenuating atherosclerosis and ischemia/reperfusion injury; (5) management of patients with arterial vascular disease; and (6) pathogenesis of venous thrombosis and late consequences of venous thromboembolism.

Original languageEnglish
Pages (from-to)538-564
Number of pages27
JournalThrombosis and Haemostasis
Issue number4
Publication statusPublished - Apr 2020
Externally publishedYes


  • Coagulation
  • Inflammation
  • Myocardial infarction
  • Platelets
  • Pulmonary embolism
  • Stroke
  • Thrombosis

Cite this