GPCR transactivation of PTKRs and TGF-aRs mediates proteoglycan synthesis in human VSMC. Results: Transactivation of TGF-aRs is integrin-dependent, and inhibition of both transactivation pathways blocks proteoglycan synthesis. Conclusion: GPCR utilize transactivation pathways and not classical signaling in proteoglycan synthesis. Significance: GPCR transactivation of receptor kinase pathways may be broader and more significant than previously recognized.
|Pages (from-to)||7410 - 7419|
|Number of pages||10|
|Journal||Journal of Biological Chemistry|
|Publication status||Published - 2013|