Thrombin-mediated proteoglycan synthesis utilizes both protein-tyrosine kinase and serine/threonine kinase receptor transactivation in vascular smooth muscle cells

Micah L Burch, Robel Getachew, Narin Osman, Mark Anthony Febbraio, Peter J Little

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Abstract

GPCR transactivation of PTKRs and TGF-aRs mediates proteoglycan synthesis in human VSMC. Results: Transactivation of TGF-aRs is integrin-dependent, and inhibition of both transactivation pathways blocks proteoglycan synthesis. Conclusion: GPCR utilize transactivation pathways and not classical signaling in proteoglycan synthesis. Significance: GPCR transactivation of receptor kinase pathways may be broader and more significant than previously recognized.
Original languageEnglish
Pages (from-to)7410 - 7419
Number of pages10
JournalThe Journal of Biological Chemistry
Volume288
Issue number10
DOIs
Publication statusPublished - 2013

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