Three-dimensional numerical simulations of pulsatile blood flow in mouse aortic arch around atherosclerotic plaques

J. P. Hough, P. Assemat, K. K. Siu, J. A. Armitage, K. G. Contreras, A. Aprico, K. Andrews, A. Dart, J. Chin-Dusting, K. Hourigan

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Abstract

Atherosclerotic plaques develop at particular sites in the arterial tree, and this regional localisation depends largely on hemodynamic parameters (such as wall shear stress; WSS) as described in the literature. Plaque rupture can result in heart attack or stroke and hence understanding the development and vulnerability of atherosclerotic plaques is critically important. The purpose of this study is to characterise the hemodynamics of blood flow in the mouse aortic arch using numerical modelling. The geometries are digitalised from synchrotron imaging and realistic pulsatile blood flow is considered. In addition, this project seeks to validate a numerical approach that is adaptable to fluid structure interaction methods. Two cases are considered; arteries with and without plaque. The time-averaged WSS distribution in the absence of plaque is qualitatively similar to other results presented in the literature. The presence of plaque was shown to alter the blood flow and hence WSS distribution, with regions of localised high WSS on the wall of the brachiocephalic artery where luminal narrowing is most pronounced.
Original languageEnglish
Title of host publicationProceedings of the Eighteenth Australasian Fluid Mechanics Conference
Subtitle of host publicationAustralian Maritime College, University of Tasmania, Launceston, Australia, 3-7 December 2012
EditorsP. A. Brandner, B. W. Pearce
PublisherAustralasian Fluid Mechanics Society
Number of pages4
ISBN (Electronic)9780646583730 (USB)
Publication statusPublished - 2012
EventAustralasian Fluid Mechanics Conference 2012 - University of Tasmania (Newnham Campus), Launceston, Australia
Duration: 3 Dec 20127 Dec 2012
Conference number: 18th
http://www.18afmc.com.au/

Conference

ConferenceAustralasian Fluid Mechanics Conference 2012
Abbreviated titleAFMC 2012
CountryAustralia
CityLaunceston
Period3/12/127/12/12
OtherThe 18th AFMC is to be the 1st of a series which will be held every 2 years by The Australasian Fluid Mechanics Society.
Internet address

Cite this

Hough, J. P., Assemat, P., Siu, K. K., Armitage, J. A., Contreras, K. G., Aprico, A., ... Hourigan, K. (2012). Three-dimensional numerical simulations of pulsatile blood flow in mouse aortic arch around atherosclerotic plaques. In P. A. Brandner, & B. W. Pearce (Eds.), Proceedings of the Eighteenth Australasian Fluid Mechanics Conference: Australian Maritime College, University of Tasmania, Launceston, Australia, 3-7 December 2012 Australasian Fluid Mechanics Society.
Hough, J. P. ; Assemat, P. ; Siu, K. K. ; Armitage, J. A. ; Contreras, K. G. ; Aprico, A. ; Andrews, K. ; Dart, A. ; Chin-Dusting, J. ; Hourigan, K. / Three-dimensional numerical simulations of pulsatile blood flow in mouse aortic arch around atherosclerotic plaques. Proceedings of the Eighteenth Australasian Fluid Mechanics Conference: Australian Maritime College, University of Tasmania, Launceston, Australia, 3-7 December 2012. editor / P. A. Brandner ; B. W. Pearce. Australasian Fluid Mechanics Society, 2012.
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abstract = "Atherosclerotic plaques develop at particular sites in the arterial tree, and this regional localisation depends largely on hemodynamic parameters (such as wall shear stress; WSS) as described in the literature. Plaque rupture can result in heart attack or stroke and hence understanding the development and vulnerability of atherosclerotic plaques is critically important. The purpose of this study is to characterise the hemodynamics of blood flow in the mouse aortic arch using numerical modelling. The geometries are digitalised from synchrotron imaging and realistic pulsatile blood flow is considered. In addition, this project seeks to validate a numerical approach that is adaptable to fluid structure interaction methods. Two cases are considered; arteries with and without plaque. The time-averaged WSS distribution in the absence of plaque is qualitatively similar to other results presented in the literature. The presence of plaque was shown to alter the blood flow and hence WSS distribution, with regions of localised high WSS on the wall of the brachiocephalic artery where luminal narrowing is most pronounced.",
author = "Hough, {J. P.} and P. Assemat and Siu, {K. K.} and Armitage, {J. A.} and Contreras, {K. G.} and A. Aprico and K. Andrews and A. Dart and J. Chin-Dusting and K. Hourigan",
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Hough, JP, Assemat, P, Siu, KK, Armitage, JA, Contreras, KG, Aprico, A, Andrews, K, Dart, A, Chin-Dusting, J & Hourigan, K 2012, Three-dimensional numerical simulations of pulsatile blood flow in mouse aortic arch around atherosclerotic plaques. in PA Brandner & BW Pearce (eds), Proceedings of the Eighteenth Australasian Fluid Mechanics Conference: Australian Maritime College, University of Tasmania, Launceston, Australia, 3-7 December 2012. Australasian Fluid Mechanics Society, Australasian Fluid Mechanics Conference 2012, Launceston, Australia, 3/12/12.

Three-dimensional numerical simulations of pulsatile blood flow in mouse aortic arch around atherosclerotic plaques. / Hough, J. P. ; Assemat, P.; Siu, K. K.; Armitage, J. A.; Contreras, K. G.; Aprico, A.; Andrews, K.; Dart, A.; Chin-Dusting, J.; Hourigan, K.

Proceedings of the Eighteenth Australasian Fluid Mechanics Conference: Australian Maritime College, University of Tasmania, Launceston, Australia, 3-7 December 2012. ed. / P. A. Brandner; B. W. Pearce. Australasian Fluid Mechanics Society, 2012.

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

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AB - Atherosclerotic plaques develop at particular sites in the arterial tree, and this regional localisation depends largely on hemodynamic parameters (such as wall shear stress; WSS) as described in the literature. Plaque rupture can result in heart attack or stroke and hence understanding the development and vulnerability of atherosclerotic plaques is critically important. The purpose of this study is to characterise the hemodynamics of blood flow in the mouse aortic arch using numerical modelling. The geometries are digitalised from synchrotron imaging and realistic pulsatile blood flow is considered. In addition, this project seeks to validate a numerical approach that is adaptable to fluid structure interaction methods. Two cases are considered; arteries with and without plaque. The time-averaged WSS distribution in the absence of plaque is qualitatively similar to other results presented in the literature. The presence of plaque was shown to alter the blood flow and hence WSS distribution, with regions of localised high WSS on the wall of the brachiocephalic artery where luminal narrowing is most pronounced.

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Hough JP, Assemat P, Siu KK, Armitage JA, Contreras KG, Aprico A et al. Three-dimensional numerical simulations of pulsatile blood flow in mouse aortic arch around atherosclerotic plaques. In Brandner PA, Pearce BW, editors, Proceedings of the Eighteenth Australasian Fluid Mechanics Conference: Australian Maritime College, University of Tasmania, Launceston, Australia, 3-7 December 2012. Australasian Fluid Mechanics Society. 2012