Abstract
Cancer is an evolving, dynamic, evasive and heterogeneous disease, characterized by high morbidity and mortality. It is widely acknowledged that the tumor microenvironment plays a fundamental role in cancer development and progression. Despite this, most in vitro cancer models are simple, two-dimensional monocultures of immortalized tumor cell lines. There is an immediate need to develop three-dimensional, multicellular biomimetic in vitro constructs that can model specific stages of tumorigenesis to aid cancer research and drug discovery. This chapter aims to review the latest advances in three-dimensional bioengineered cancer modeling, with particular focus on models that retain the biological and physical characteristics of the in vivo tumor microenvironment.
| Original language | English |
|---|---|
| Title of host publication | Comprehensive Biomaterials II |
| Editors | Paul Ducheyne, David W. Grainger, Kevin E. Healy, Dietmar W. Hutmacher, C. James Kirkpatrick |
| Publisher | Elsevier |
| Chapter | 5.17 |
| Pages | 303-328 |
| Number of pages | 26 |
| Volume | 5 |
| ISBN (Electronic) | 9780081006924 |
| ISBN (Print) | 9780081006917 |
| DOIs | |
| Publication status | Published - 29 May 2017 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Bioengineering
- Cancer
- Cancer models
- Drug resistance
- Drug screening
- Electrospinning
- Hallmarks of Cancer
- Hydrogels
- In vitro
- Malignancy
- Microfluidics
- Modeling
- Organ-on-a-chip
- Organoids
- Scaffolds
- Spheroids
- Three-dimensional culture
- Tumor microenvironment
- Tumor-on-a-chip
- Tumorigenesis
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