Three-Dimensional Bioengineered Cancer Models

Brooke Anne Pereira; Natalie Louise Lister; Elena M De-Juan-Pardo; Gail Petuna Risbridger; Stuart John Ellem

doi:10.1016/B978-0-12-803581-8.09297-3

Three-Dimensional Bioengineered Cancer Models

Brooke Anne Pereira, Natalie Louise Lister, Elena M De-Juan-Pardo, Gail Petuna Risbridger, Stuart John Ellem

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

4 Citations (Scopus)

Abstract

Cancer is an evolving, dynamic, evasive and heterogeneous disease, characterized by high morbidity and mortality. It is widely acknowledged that the tumor microenvironment plays a fundamental role in cancer development and progression. Despite this, most in vitro cancer models are simple, two-dimensional monocultures of immortalized tumor cell lines. There is an immediate need to develop three-dimensional, multicellular biomimetic in vitro constructs that can model specific stages of tumorigenesis to aid cancer research and drug discovery. This chapter aims to review the latest advances in three-dimensional bioengineered cancer modeling, with particular focus on models that retain the biological and physical characteristics of the in vivo tumor microenvironment.

Original language	English
Title of host publication	Comprehensive Biomaterials II
Editors	Paul Ducheyne, David W. Grainger, Kevin E. Healy, Dietmar W. Hutmacher, C. James Kirkpatrick
Publisher	Elsevier
Chapter	5.17
Pages	303-328
Number of pages	26
Volume	5
ISBN (Electronic)	9780081006924
ISBN (Print)	9780081006917
DOIs	https://doi.org/10.1016/B978-0-12-803581-8.09297-3
Publication status	Published - 29 May 2017

Keywords

Bioengineering
Cancer
Cancer models
Drug resistance
Drug screening
Electrospinning
Hallmarks of Cancer
Hydrogels
In vitro
Malignancy
Microfluidics
Modeling
Organ-on-a-chip
Organoids
Scaffolds
Spheroids
Three-dimensional culture
Tumor microenvironment
Tumor-on-a-chip
Tumorigenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/B978-0-12-803581-8.09297-3

Cite this

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abstract = "Cancer is an evolving, dynamic, evasive and heterogeneous disease, characterized by high morbidity and mortality. It is widely acknowledged that the tumor microenvironment plays a fundamental role in cancer development and progression. Despite this, most in vitro cancer models are simple, two-dimensional monocultures of immortalized tumor cell lines. There is an immediate need to develop three-dimensional, multicellular biomimetic in vitro constructs that can model specific stages of tumorigenesis to aid cancer research and drug discovery. This chapter aims to review the latest advances in three-dimensional bioengineered cancer modeling, with particular focus on models that retain the biological and physical characteristics of the in vivo tumor microenvironment.",

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Three-Dimensional Bioengineered Cancer Models. / Pereira, Brooke Anne; Lister, Natalie Louise; De-Juan-Pardo, Elena M et al.
Comprehensive Biomaterials II. ed. / Paul Ducheyne; David W. Grainger; Kevin E. Healy; Dietmar W. Hutmacher; C. James Kirkpatrick. Vol. 5 Elsevier, 2017. p. 303-328.

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

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AU - Lister, Natalie Louise

AU - De-Juan-Pardo, Elena M

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AU - Ellem, Stuart John

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KW - Microfluidics

KW - Modeling

KW - Organ-on-a-chip

KW - Organoids

KW - Scaffolds

KW - Spheroids

KW - Three-dimensional culture

KW - Tumor microenvironment

KW - Tumor-on-a-chip

KW - Tumorigenesis

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ER -

Three-Dimensional Bioengineered Cancer Models

Abstract

Keywords

UN SDGs

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