Three-Dimensional Bioengineered Cancer Models

Brooke Anne Pereira, Natalie Louise Lister, Elena M De-Juan-Pardo, Gail Petuna Risbridger, Stuart John Ellem

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

4 Citations (Scopus)


Cancer is an evolving, dynamic, evasive and heterogeneous disease, characterized by high morbidity and mortality. It is widely acknowledged that the tumor microenvironment plays a fundamental role in cancer development and progression. Despite this, most in vitro cancer models are simple, two-dimensional monocultures of immortalized tumor cell lines. There is an immediate need to develop three-dimensional, multicellular biomimetic in vitro constructs that can model specific stages of tumorigenesis to aid cancer research and drug discovery. This chapter aims to review the latest advances in three-dimensional bioengineered cancer modeling, with particular focus on models that retain the biological and physical characteristics of the in vivo tumor microenvironment.

Original languageEnglish
Title of host publicationComprehensive Biomaterials II
EditorsPaul Ducheyne, David W. Grainger, Kevin E. Healy, Dietmar W. Hutmacher, C. James Kirkpatrick
Number of pages26
ISBN (Electronic)9780081006924
ISBN (Print)9780081006917
Publication statusPublished - 29 May 2017


  • Bioengineering
  • Cancer
  • Cancer models
  • Drug resistance
  • Drug screening
  • Electrospinning
  • Hallmarks of Cancer
  • Hydrogels
  • In vitro
  • Malignancy
  • Microfluidics
  • Modeling
  • Organ-on-a-chip
  • Organoids
  • Scaffolds
  • Spheroids
  • Three-dimensional culture
  • Tumor microenvironment
  • Tumor-on-a-chip
  • Tumorigenesis

Cite this