Third form of the precursor to the major merozoite surface antigens of Plasmodium falciparum.

M. G. Peterson; R. L. Coppel; M. B. Moloney; D. J. Kemp

doi:10.1128/MCB.8.6.2664

Third form of the precursor to the major merozoite surface antigens of Plasmodium falciparum.

M. G. Peterson, R. L. Coppel, M. B. Moloney, D. J. Kemp

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Abstract

The precursor to the major merozoite surface antigens of Plasmodium falciparum appears to be encoded by two distinctly different (dimorphic) alleles able to undergo limited recombination. We analyzed 18 previously uncharacterized P. falciparum isolates to test the dimorphic model. All but one, a Thailand isolate, conformed to the dimorphic model, and this isolate conformed to the dimorphic model in all but variable block 2. Sequence analysis revealed that block 2 of isolate CSL2 was a third form. Hence, the dimorphic model is not strictly correct. Recombination between alleles was found only within two conserved blocks near the 5' end of the gene.

Original language	English
Pages (from-to)	2664-2667
Number of pages	4
Journal	Molecular and Cellular Biology
Volume	8
Issue number	6
DOIs	https://doi.org/10.1128/MCB.8.6.2664
Publication status	Published - 1 Jan 1988
Externally published	Yes

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AU - Kemp, D. J.

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AB - The precursor to the major merozoite surface antigens of Plasmodium falciparum appears to be encoded by two distinctly different (dimorphic) alleles able to undergo limited recombination. We analyzed 18 previously uncharacterized P. falciparum isolates to test the dimorphic model. All but one, a Thailand isolate, conformed to the dimorphic model, and this isolate conformed to the dimorphic model in all but variable block 2. Sequence analysis revealed that block 2 of isolate CSL2 was a third form. Hence, the dimorphic model is not strictly correct. Recombination between alleles was found only within two conserved blocks near the 5' end of the gene.

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Third form of the precursor to the major merozoite surface antigens of Plasmodium falciparum.

Abstract

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