Thiol-based redox proteomics in cancer research

Kefei Yuan, Yuan Liu, Haining Chen, Lu Zhang, Jiang Lan, Wei Gao, Qianhui Dou, Edouard C Nice, Canhua Huang

Research output: Contribution to journalArticleResearchpeer-review

17 Citations (Scopus)

Abstract

Cancer cells maintain their intracellular reactive oxygen species (ROS) concentrations at required levels for their survival. Changes in ROS concentrations can regulate biochemical signaling mechanisms that control cell function. It has been demonstrated that ROS regulate the cellular events through redox regulation of redox-sensitive proteins (redox sensors). Upon oxidative stress, redox sensors undergo redox modifications that cause the allosteric changes of these proteins and endows them with different functions. Understanding the altered functions of redox sensors and the underlying mechanisms is critical for the development of novel cancer therapeutics. Recently, a series of high throughput proteomics approaches have been developed for screening redox processes. In this manuscript, we review these methodologies and discuss the important redox sensors recently identified that are related to cancer. This article is protected by copyright. All rights reserved.
Original languageEnglish
Pages (from-to)287 - 299
Number of pages13
JournalProteomics
Volume15
Issue number2-3
DOIs
Publication statusPublished - 2015

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