Thinking about broadly cross-reactive vaccines

Peter C Doherty; S. J. Turner

doi:10.1038/clpt.2009.52

Thinking about broadly cross-reactive vaccines

Peter C Doherty
, S. J. Turner

Research output: Contribution to journal › Review Article › Research › peer-review

3 Citations (Scopus)

Abstract

Successful vaccines function almost exclusively by establishing long-lived plasma cells that secrete antibody into the blood and at mucosal sites. Some pathogens, such as HIV and the influenza A viruses, use a mutational strategy to escape neutralization by antibodies specific for surface glycoproteins.The CD8+ cytotoxic T-lymphocyte (CTL) response is, on the other hand, directed mostly at peptides derived from conserved, internal virus proteins. Can CTL memory be manipulated to provide cross-reactive protection?

Original language	English
Pages (from-to)	665-668
Number of pages	4
Journal	Clinical Pharmacology and Therapeutics
Volume	85
Issue number	6
DOIs	https://doi.org/10.1038/clpt.2009.52
Publication status	Published - Jun 2009
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1038/clpt.2009.52

Cite this

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title = "Thinking about broadly cross-reactive vaccines",

abstract = "Successful vaccines function almost exclusively by establishing long-lived plasma cells that secrete antibody into the blood and at mucosal sites. Some pathogens, such as HIV and the influenza A viruses, use a mutational strategy to escape neutralization by antibodies specific for surface glycoproteins.The CD8+ cytotoxic T-lymphocyte (CTL) response is, on the other hand, directed mostly at peptides derived from conserved, internal virus proteins. Can CTL memory be manipulated to provide cross-reactive protection?",

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AU - Turner, S. J.

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AB - Successful vaccines function almost exclusively by establishing long-lived plasma cells that secrete antibody into the blood and at mucosal sites. Some pathogens, such as HIV and the influenza A viruses, use a mutational strategy to escape neutralization by antibodies specific for surface glycoproteins.The CD8+ cytotoxic T-lymphocyte (CTL) response is, on the other hand, directed mostly at peptides derived from conserved, internal virus proteins. Can CTL memory be manipulated to provide cross-reactive protection?

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ER -

Thinking about broadly cross-reactive vaccines

Abstract

UN SDGs

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