Thinking about broadly cross-reactive vaccines

Peter C Doherty, S. J. Turner

Research output: Contribution to journalReview ArticleResearchpeer-review

3 Citations (Scopus)


Successful vaccines function almost exclusively by establishing long-lived plasma cells that secrete antibody into the blood and at mucosal sites. Some pathogens, such as HIV and the influenza A viruses, use a mutational strategy to escape neutralization by antibodies specific for surface glycoproteins.The CD8+ cytotoxic T-lymphocyte (CTL) response is, on the other hand, directed mostly at peptides derived from conserved, internal virus proteins. Can CTL memory be manipulated to provide cross-reactive protection?

Original languageEnglish
Pages (from-to)665-668
Number of pages4
JournalClinical Pharmacology & Therapeutics
Issue number6
Publication statusPublished - Jun 2009
Externally publishedYes

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