Therapies for hyperglycaemia-induced diabetic complications

From animal models to clinical trials

Nigel A. Calcutt, Mark E. Cooper, Tim S. Kern, Ann Marie Schmidt

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Long-term diabetes increases the likelihood of developing secondary damage to numerous systems, and these complications represent a substantial cause of morbidity and mortality. Establishing the causes of diabetes remains the key step towards eradicating the disease, but the prevention and amelioration of diabetic complications is equally important for the millions of individuals who already have the disease or are likely to develop it before prophylaxis or a cure become routinely available. In this Review, we focus on four common complications of diabetes, discuss the range of pathologies that are precipitated by hyperglycaemia and highlight emerging targets for therapeutic intervention.

Original languageEnglish
Pages (from-to)417-429
Number of pages13
JournalNature Reviews Drug Discovery
Volume8
Issue number5
DOIs
Publication statusPublished - 2009
Externally publishedYes

Cite this

Calcutt, Nigel A. ; Cooper, Mark E. ; Kern, Tim S. ; Schmidt, Ann Marie. / Therapies for hyperglycaemia-induced diabetic complications : From animal models to clinical trials. In: Nature Reviews Drug Discovery. 2009 ; Vol. 8, No. 5. pp. 417-429.
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Therapies for hyperglycaemia-induced diabetic complications : From animal models to clinical trials. / Calcutt, Nigel A.; Cooper, Mark E.; Kern, Tim S.; Schmidt, Ann Marie.

In: Nature Reviews Drug Discovery, Vol. 8, No. 5, 2009, p. 417-429.

Research output: Contribution to journalReview ArticleResearchpeer-review

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