TY - JOUR
T1 - Therapeutic potential of mangiferin against kidney disorders and its mechanism of action
T2 - A review
AU - Lum, Pei Teng
AU - Sekar, Mahendran
AU - Gan, Siew Hua
AU - Jeyabalan, Srikanth
AU - Bonam, Srinivasa Reddy
AU - Rani, Nur Najihah Izzati Mat
AU - Ku-Mahdzir, Ku-Marina
AU - Seow, Lay Jing
AU - Wu, Yuan Seng
AU - Subramaniyan, Vetriselvan
AU - Fuloria, Neeraj Kumar
AU - Fuloria, Shivkanya
N1 - Funding Information:
The authors thank the Ministry of Higher Education (MOHE) Malaysia for the financial support provided via the Fundamental Research Grant Scheme [Ref: FRGS/1/2020/SKK06/UNIKL/02/4]. The authors also would like to acknowledge Universiti Kuala Lumpur Royal College of Medicine Perak, Malaysia for providing the necessary facilities and resources to complete the study. The figures were created with the support of BioRender.com under a paid subscription. SRB grateful to the Prof. Jagadeesh Bayry (INSERM, Centre de Recherche des Cordeliers, Sorbonne Universit?s, Universit? de Paris, France and IIT Palakkad, Palakkad, Kerala, India) for providing post-doctoral position.
Funding Information:
The authors thank the Ministry of Higher Education (MOHE) Malaysia for the financial support provided via the Fundamental Research Grant Scheme [Ref: FRGS/1/2020/SKK06/UNIKL/02/4]. The authors also would like to acknowledge Universiti Kuala Lumpur Royal College of Medicine Perak, Malaysia for providing the necessary facilities and resources to complete the study. The figures were created with the support of BioRender.com under a paid subscription. SRB grateful to the Prof. Jagadeesh Bayry (INSERM, Centre de Recherche des Cordeliers, Sorbonne Universités, Université de Paris, France and IIT Palakkad, Palakkad, Kerala, India) for providing post-doctoral position.
Publisher Copyright:
© 2021 The Author(s)
PY - 2022/3
Y1 - 2022/3
N2 - There is a swing in research developments concerning the utilization of natural products as effective pharmacotherapeutic agents due to their comparatively lower toxicities than synthetic compounds. Among natural products, mangiferin is a natural C-glucosyl xanthonoid polyphenol with remarkable pharmacological activities. Emerging evidence indicates the therapeutic benefits of mangiferin against various kidney disorders, including renal injury, diabetic nephropathy, renal fibrosis, hyperuricemic nephropathy, and lupus nephritis, in experimental animal models. The mangiferin induced antioxidant response resulting in vital functions, such as protection against renal inflammation, inhibits renal cell apoptosis, activates autophagy, causes immunomodulation, regulates renal urate transporters and modulates cell signalling pathways. The purpose of this review provide a brief overview of the in vitro/in vivo reno-protective effect of mangiferin and the underlying mechanism(s) in protecting against kidney disorders. Understanding the pharmacological actions of mangiferin is prominence due to its excellent therapeutic potential in managing kidney disorders. Thus, in addition to this review, in-silico molecular docking is performed against nuclear factor kappa B (NF-κB) and soluble epoxide hydrolase (sEH) to study the mechanism of action of mangiferin. It is believed that mangiferin is a safe reno-protective molecule. The observed positive effects are attributed to the inhibition of inflammation caused by NF-κB and sEH upregulation and oxidative stress activation. Studies on the efficacy and safety of mangiferin in clinical trials are further warranted to confirm its medicinal potential as therapeutic agent for kidney disorders in humans.
AB - There is a swing in research developments concerning the utilization of natural products as effective pharmacotherapeutic agents due to their comparatively lower toxicities than synthetic compounds. Among natural products, mangiferin is a natural C-glucosyl xanthonoid polyphenol with remarkable pharmacological activities. Emerging evidence indicates the therapeutic benefits of mangiferin against various kidney disorders, including renal injury, diabetic nephropathy, renal fibrosis, hyperuricemic nephropathy, and lupus nephritis, in experimental animal models. The mangiferin induced antioxidant response resulting in vital functions, such as protection against renal inflammation, inhibits renal cell apoptosis, activates autophagy, causes immunomodulation, regulates renal urate transporters and modulates cell signalling pathways. The purpose of this review provide a brief overview of the in vitro/in vivo reno-protective effect of mangiferin and the underlying mechanism(s) in protecting against kidney disorders. Understanding the pharmacological actions of mangiferin is prominence due to its excellent therapeutic potential in managing kidney disorders. Thus, in addition to this review, in-silico molecular docking is performed against nuclear factor kappa B (NF-κB) and soluble epoxide hydrolase (sEH) to study the mechanism of action of mangiferin. It is believed that mangiferin is a safe reno-protective molecule. The observed positive effects are attributed to the inhibition of inflammation caused by NF-κB and sEH upregulation and oxidative stress activation. Studies on the efficacy and safety of mangiferin in clinical trials are further warranted to confirm its medicinal potential as therapeutic agent for kidney disorders in humans.
KW - Drug delivery
KW - In-silico
KW - Kidney disorders
KW - Mangifera indica
KW - Mangiferin
KW - Reno-protective
UR - http://www.scopus.com/inward/record.url?scp=85120379229&partnerID=8YFLogxK
U2 - 10.1016/j.sjbs.2021.11.016
DO - 10.1016/j.sjbs.2021.11.016
M3 - Review Article
C2 - 35280538
AN - SCOPUS:85120379229
SN - 1319-562X
VL - 29
SP - 1530
EP - 1542
JO - Saudi Journal of Biological Sciences
JF - Saudi Journal of Biological Sciences
IS - 3
ER -
