Therapeutic potential of Liver Receptor Homolog-1 modulators

Kyren Lazarus; Dhilushi Wijayakumara; Ashwini L Chand; Evan R Simpson; Colin Clyne

doi:10.1016/j.jsbmb.2011.12.017

Therapeutic potential of Liver Receptor Homolog-1 modulators

Kyren Lazarus
, Dhilushi Wijayakumara
, Ashwini L Chand
, Evan R Simpson
, Colin Clyne

Biochemistry & Molecular Biology

Research output: Contribution to journal › Article › Research › peer-review

53 Citations (Scopus)

Abstract

Liver Receptor Homolog-1 (LRH-1; NR5A2) belongs to the orphan nuclear receptor superfamily, and plays vital roles in early development, cholesterol homeostasis, steroidogenesis and certain diseases, including cancer. It is expressed in embryonic stem cells, adult liver, intestine, pancreas and ovary. It binds to DNA as a monomer and is regulated by various ligand-dependent and -independent mechanisms. Recent work identified synthetic ligands for LRH-1; such compounds may yield useful therapeutics for a range of pathologic conditions associated with aberrant expression and activity of LRH-1.

Original language	English
Pages (from-to)	138 - 146
Number of pages	9
Journal	The Journal of Steroid Biochemistry and Molecular Biology
Volume	130
Issue number	3-5
DOIs	https://doi.org/10.1016/j.jsbmb.2011.12.017
Publication status	Published - 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

LRH-1
NR5A2
Orphan nuclear receptor

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10.1016/j.jsbmb.2011.12.017

Cite this

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title = "Therapeutic potential of Liver Receptor Homolog-1 modulators",

abstract = "Liver Receptor Homolog-1 (LRH-1; NR5A2) belongs to the orphan nuclear receptor superfamily, and plays vital roles in early development, cholesterol homeostasis, steroidogenesis and certain diseases, including cancer. It is expressed in embryonic stem cells, adult liver, intestine, pancreas and ovary. It binds to DNA as a monomer and is regulated by various ligand-dependent and -independent mechanisms. Recent work identified synthetic ligands for LRH-1; such compounds may yield useful therapeutics for a range of pathologic conditions associated with aberrant expression and activity of LRH-1.",

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year = "2012",

doi = "10.1016/j.jsbmb.2011.12.017",

language = "English",

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pages = "138 -- 146",

journal = "The Journal of Steroid Biochemistry and Molecular Biology",

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TY - JOUR

T1 - Therapeutic potential of Liver Receptor Homolog-1 modulators

AU - Lazarus, Kyren

AU - Wijayakumara, Dhilushi

AU - Chand, Ashwini L

AU - Simpson, Evan R

AU - Clyne, Colin

PY - 2012

Y1 - 2012

N2 - Liver Receptor Homolog-1 (LRH-1; NR5A2) belongs to the orphan nuclear receptor superfamily, and plays vital roles in early development, cholesterol homeostasis, steroidogenesis and certain diseases, including cancer. It is expressed in embryonic stem cells, adult liver, intestine, pancreas and ovary. It binds to DNA as a monomer and is regulated by various ligand-dependent and -independent mechanisms. Recent work identified synthetic ligands for LRH-1; such compounds may yield useful therapeutics for a range of pathologic conditions associated with aberrant expression and activity of LRH-1.

AB - Liver Receptor Homolog-1 (LRH-1; NR5A2) belongs to the orphan nuclear receptor superfamily, and plays vital roles in early development, cholesterol homeostasis, steroidogenesis and certain diseases, including cancer. It is expressed in embryonic stem cells, adult liver, intestine, pancreas and ovary. It binds to DNA as a monomer and is regulated by various ligand-dependent and -independent mechanisms. Recent work identified synthetic ligands for LRH-1; such compounds may yield useful therapeutics for a range of pathologic conditions associated with aberrant expression and activity of LRH-1.

KW - LRH-1

KW - NR5A2

KW - Orphan nuclear receptor

UR - http://www.sciencedirect.com/science/article/pii/S0960076011002597

U2 - 10.1016/j.jsbmb.2011.12.017

DO - 10.1016/j.jsbmb.2011.12.017

M3 - Article

SN - 0960-0760

VL - 130

SP - 138

EP - 146

JO - The Journal of Steroid Biochemistry and Molecular Biology

JF - The Journal of Steroid Biochemistry and Molecular Biology

IS - 3-5

ER -

Therapeutic potential of Liver Receptor Homolog-1 modulators

Abstract

UN SDGs

Keywords

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