Therapeutic potential of Liver Receptor Homolog-1 modulators

Kyren Lazarus, Dhilushi Wijayakumara, Ashwini L Chand, Evan R Simpson, Colin Clyne

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37 Citations (Scopus)


Liver Receptor Homolog-1 (LRH-1; NR5A2) belongs to the orphan nuclear receptor superfamily, and plays vital roles in early development, cholesterol homeostasis, steroidogenesis and certain diseases, including cancer. It is expressed in embryonic stem cells, adult liver, intestine, pancreas and ovary. It binds to DNA as a monomer and is regulated by various ligand-dependent and -independent mechanisms. Recent work identified synthetic ligands for LRH-1; such compounds may yield useful therapeutics for a range of pathologic conditions associated with aberrant expression and activity of LRH-1.
Original languageEnglish
Pages (from-to)138 - 146
Number of pages9
JournalJournal of Steroid Biochemistry and Molecular Biology
Issue number3-5
Publication statusPublished - 2012


  • LRH-1
  • NR5A2
  • Orphan nuclear receptor

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