Therapeutic Potential of Intravenous Phage as Standalone Therapy for Recurrent Drug-Resistant Urinary Tract Infections

Tram Le, Sue C. Nang, Jinxin Zhao, Heidi H. Yu, Jian Li, Jason J. Gill, Mei Liu, Saima Aslam

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11 Citations (Scopus)

Abstract

Recurrent urinary tract infections (rUTI) are common in kidney transplant recipients (KTR) and are associated with multidrug resistance and increased morbidity/ mortality. Novel antibiotic alternatives to reduce UTI recurrence are critically needed. We describe a case of rUTI due to extended spectrum beta lactamase (ESBL) Klebsiella pneumoniae in a KTR that was treated successfully with 4 weeks of adjunctive intravenous bacteriophage therapy alone, without concomitant antibiotics, and with no recurrence in a year of follow-up.

Original languageEnglish
Article numbere00037-23
Number of pages7
JournalAntimicrobial Agents and Chemotherapy
Volume67
Issue number4
DOIs
Publication statusPublished - Apr 2023

Keywords

  • bacteriophage
  • ESBL
  • kidney transplant
  • phage
  • rUTI

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