Abstract
Therapeutic monoclonal antibodies (mAbs) are the fastest growing area of drug development, with an increasing number of diseases, including rheumatoid arthritis, multiple sclerosis and various forms of cancer, now amenable to treatment. Therapeutic mAbs bind to proteins or cells that are involved in the development of disease, impairing their ability to further contribute to the pathology. Currently, the treatment of acute and chronic wounds is an area of unmet clinical need. There are a number of proteins and cell types that are detrimental to wound healing and are up-regulated in the wound environment, especially in chronic wounds, with a reduction expected to improve healing outcomes. Therapeutic mAbs may therefore potentially provide a valuable new tool for wound treatment. This review explores the application of mAb therapies in wound healing.
| Original language | English |
|---|---|
| Number of pages | 9 |
| Journal | Wound Practice and Research |
| Volume | 23 |
| Issue number | 1 |
| Publication status | Published - 2015 |
| Externally published | Yes |
