The Zebrafish Cerebellum

Jan Kaslin; Michael Brand

doi:10.1007/978-3-031-15070-8_61

The Zebrafish Cerebellum

Jan Kaslin, Michael Brand

Australian Regenerative Medicine Institute

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

Abstract

The general architecture and cellular composition of the cerebellum is highly conserved within the vertebrate lineage enabling relevant comparative studies at gene and cell level. The zebrafish model is ideally suited for studies on cerebellar development and function as it’s rapid external development enable direct visualisation of cells and events at single cell resolution. Furthermore, the versatile toolbox for genetic manipulation to generate mutants and genetically encoded fluorescent reporters or sensors enables functional studies at cell, circuit and physiological level in vivo.

Original language	English
Title of host publication	Essentials of Cerebellum and Cerebellar Disorders
Subtitle of host publication	A Primer For Graduate Students
Editors	Donna L. Gruol, Noriyuki Koibuchi, Mario Manto, Marco Molinari, Jeremy D. Schmahmann, Ying Shen
Place of Publication	Switzerland
Publisher	Springer
Chapter	61
Pages	393-398
Number of pages	6
Edition	2nd
ISBN (Electronic)	9783031150708
ISBN (Print)	9783031150692
DOIs	https://doi.org/10.1007/978-3-031-15070-8_61
Publication status	Published - 2023

Keywords

Adult neurogenesis
Cerebellar development
Eurydendroid cell
Fish
Genetic model
In vivo imaging
Isthmic organizer
Mid-hindbrain boundary
Morphogenesis
Mutant
Screening
Teleost
Zebrafish

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10.1007/978-3-031-15070-8_61

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The Zebrafish Cerebellum. / Kaslin, Jan; Brand, Michael.
Essentials of Cerebellum and Cerebellar Disorders: A Primer For Graduate Students. ed. / Donna L. Gruol; Noriyuki Koibuchi; Mario Manto; Marco Molinari; Jeremy D. Schmahmann; Ying Shen. 2nd. ed. Switzerland: Springer, 2023. p. 393-398.

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

TY - CHAP

T1 - The Zebrafish Cerebellum

AU - Kaslin, Jan

AU - Brand, Michael

N1 - Publisher Copyright: © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2016, 2023.

PY - 2023

Y1 - 2023

N2 - The general architecture and cellular composition of the cerebellum is highly conserved within the vertebrate lineage enabling relevant comparative studies at gene and cell level. The zebrafish model is ideally suited for studies on cerebellar development and function as it’s rapid external development enable direct visualisation of cells and events at single cell resolution. Furthermore, the versatile toolbox for genetic manipulation to generate mutants and genetically encoded fluorescent reporters or sensors enables functional studies at cell, circuit and physiological level in vivo.

AB - The general architecture and cellular composition of the cerebellum is highly conserved within the vertebrate lineage enabling relevant comparative studies at gene and cell level. The zebrafish model is ideally suited for studies on cerebellar development and function as it’s rapid external development enable direct visualisation of cells and events at single cell resolution. Furthermore, the versatile toolbox for genetic manipulation to generate mutants and genetically encoded fluorescent reporters or sensors enables functional studies at cell, circuit and physiological level in vivo.

KW - Adult neurogenesis

KW - Cerebellar development

KW - Eurydendroid cell

KW - Fish

KW - Genetic model

KW - In vivo imaging

KW - Isthmic organizer

KW - Mid-hindbrain boundary

KW - Morphogenesis

KW - Mutant

KW - Screening

KW - Teleost

KW - Zebrafish

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AN - SCOPUS:85173383387

SN - 9783031150692

SP - 393

EP - 398

BT - Essentials of Cerebellum and Cerebellar Disorders

A2 - Gruol, Donna L.

A2 - Koibuchi, Noriyuki

A2 - Manto, Mario

A2 - Molinari, Marco

A2 - Schmahmann, Jeremy D.

A2 - Shen, Ying

PB - Springer

CY - Switzerland

ER -

The Zebrafish Cerebellum

Abstract

Keywords

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The zebrafish cerebellum

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