The zebrafish cerebellum

Jan Kaslin, Michael Brand

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2 Citations (Scopus)

Abstract

The overall architecture and cell types are highly conserved from mammals to teleost fi sh. The rapid transparent ex utero development in zebrafi sh allows direct access and precise visualization of all the major events in cerebellar development. The superfi cial position of the cerebellar primoridum and cerebellum further facilitates in vivo imaging of cerebellar structures and developmental events at cell resolution. Furthermore, zebrafi sh model have a comprehensive genetic toolbox that allow forward and reverse genetic approaches to study and manipulate gene function. Consequently, zebrafi sh is emerging as an excellent vertebrate model for studies of molecular, cellular and physiological mechanisms involved in cerebellar development and function at gene, cell and circuit level.

Original languageEnglish
Title of host publicationEssentials of Cerebellum and Cerebellar Disorders: A Primer for Graduate Students
PublisherSpringer
Pages411-421
Number of pages11
ISBN (Electronic)9783319245515
ISBN (Print)9783319245492
DOIs
Publication statusPublished - 1 Jan 2016

Keywords

  • Adult neurogenesis
  • Cerebellar development
  • Eurydendroid cell
  • Fish
  • Genetic model
  • In vivo imaging
  • Isthmic organizer
  • Mid-hindbrain-boundary
  • Morphogenesis
  • Mutant
  • Screening
  • Teleost
  • Zebrafi sh

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