The zebrafish cerebellum

Jan Kaslin; Michael Brand

doi:10.1007/978-3-319-24551-5_56

The zebrafish cerebellum

Jan Kaslin, Michael Brand

Australian Regenerative Medicine Institute

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

6 Citations (Scopus)

Abstract

The overall architecture and cell types are highly conserved from mammals to teleost fi sh. The rapid transparent ex utero development in zebrafi sh allows direct access and precise visualization of all the major events in cerebellar development. The superfi cial position of the cerebellar primoridum and cerebellum further facilitates in vivo imaging of cerebellar structures and developmental events at cell resolution. Furthermore, zebrafi sh model have a comprehensive genetic toolbox that allow forward and reverse genetic approaches to study and manipulate gene function. Consequently, zebrafi sh is emerging as an excellent vertebrate model for studies of molecular, cellular and physiological mechanisms involved in cerebellar development and function at gene, cell and circuit level.

Original language	English
Title of host publication	Essentials of Cerebellum and Cerebellar Disorders
Subtitle of host publication	A Primer for Graduate Students
Publisher	Springer
Pages	411-421
Number of pages	11
Edition	1st
ISBN (Electronic)	9783319245515
ISBN (Print)	9783319245492
DOIs	https://doi.org/10.1007/978-3-319-24551-5_56
Publication status	Published - 1 Jan 2016

Keywords

Adult neurogenesis
Cerebellar development
Eurydendroid cell
Fish
Genetic model
In vivo imaging
Isthmic organizer
Mid-hindbrain-boundary
Morphogenesis
Mutant
Screening
Teleost
Zebrafi sh

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10.1007/978-3-319-24551-5_56

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AB - The overall architecture and cell types are highly conserved from mammals to teleost fi sh. The rapid transparent ex utero development in zebrafi sh allows direct access and precise visualization of all the major events in cerebellar development. The superfi cial position of the cerebellar primoridum and cerebellum further facilitates in vivo imaging of cerebellar structures and developmental events at cell resolution. Furthermore, zebrafi sh model have a comprehensive genetic toolbox that allow forward and reverse genetic approaches to study and manipulate gene function. Consequently, zebrafi sh is emerging as an excellent vertebrate model for studies of molecular, cellular and physiological mechanisms involved in cerebellar development and function at gene, cell and circuit level.

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KW - Cerebellar development

KW - Eurydendroid cell

KW - Fish

KW - Genetic model

KW - In vivo imaging

KW - Isthmic organizer

KW - Mid-hindbrain-boundary

KW - Morphogenesis

KW - Mutant

KW - Screening

KW - Teleost

KW - Zebrafi sh

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EP - 421

BT - Essentials of Cerebellum and Cerebellar Disorders

PB - Springer

ER -

The zebrafish cerebellum

Abstract

Keywords

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The Zebrafish Cerebellum

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