The wMelPop strain of Wolbachia interferes with dopamine levels in Aedes aegypti

Luciano Moreira; Yixin Ye; Karly Turner; Darryl Eyles; Elizabeth McGraw; Scott Leslie O'Neill

doi:10.1186/1756-3305-4-28

The wMelPop strain of Wolbachia interferes with dopamine levels in Aedes aegypti

Luciano Moreira, Yixin Ye, Karly Turner, Darryl Eyles, Elizabeth McGraw, Scott Leslie O'Neill

Research output: Contribution to journal › Article › Research › peer-review

26 Citations (Scopus)

Abstract

Wolbachia is an intracellular bacterium that has been stably transinfected into the mosquito vector of dengue, Aedes aegypti. This inherited infection causes a range of metabolic and phenotypic alterations in the mosquito, which might be related to neuronal abnormalities. In order to determine if these alterations were caused by the manipulation of neuroamines by this bacterium, we studied the expression of genes involved in the dopamine biosynthetic pathway and also measured the amount of dopamine in infected and uninfected mosquitoes of different ages. Wolbachia-infected mosquitoes exhibit greater expression of some genes related to the melanization pathway, but not for those directly linked to dopamine production. Although dopamine levels were higher in Wolbachia-positive mosquitoes this was not consistent across all insect ages nor was it related to the previously described Wolbachia induced bendy and shaky phenotypes.

Original language	English
Article number	28
Number of pages	5
Journal	Parasites & Vectors
Volume	4
DOIs	https://doi.org/10.1186/1756-3305-4-28
Publication status	Published - 2011
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1186/1756-3305-4-28

Cite this

@article{4a1c98df2c044b3f8bf38ec436e9ce27,

title = "The wMelPop strain of Wolbachia interferes with dopamine levels in Aedes aegypti",

abstract = "Wolbachia is an intracellular bacterium that has been stably transinfected into the mosquito vector of dengue, Aedes aegypti. This inherited infection causes a range of metabolic and phenotypic alterations in the mosquito, which might be related to neuronal abnormalities. In order to determine if these alterations were caused by the manipulation of neuroamines by this bacterium, we studied the expression of genes involved in the dopamine biosynthetic pathway and also measured the amount of dopamine in infected and uninfected mosquitoes of different ages. Wolbachia-infected mosquitoes exhibit greater expression of some genes related to the melanization pathway, but not for those directly linked to dopamine production. Although dopamine levels were higher in Wolbachia-positive mosquitoes this was not consistent across all insect ages nor was it related to the previously described Wolbachia induced bendy and shaky phenotypes.",

author = "Luciano Moreira and Yixin Ye and Karly Turner and Darryl Eyles and Elizabeth McGraw and O'Neill, {Scott Leslie}",

year = "2011",

doi = "10.1186/1756-3305-4-28",

language = "English",

volume = "4",

journal = "Parasites & Vectors",

issn = "1756-3305",

publisher = "BioMed Central",

}

TY - JOUR

T1 - The wMelPop strain of Wolbachia interferes with dopamine levels in Aedes aegypti

AU - Moreira, Luciano

AU - Ye, Yixin

AU - Turner, Karly

AU - Eyles, Darryl

AU - McGraw, Elizabeth

AU - O'Neill, Scott Leslie

PY - 2011

Y1 - 2011

N2 - Wolbachia is an intracellular bacterium that has been stably transinfected into the mosquito vector of dengue, Aedes aegypti. This inherited infection causes a range of metabolic and phenotypic alterations in the mosquito, which might be related to neuronal abnormalities. In order to determine if these alterations were caused by the manipulation of neuroamines by this bacterium, we studied the expression of genes involved in the dopamine biosynthetic pathway and also measured the amount of dopamine in infected and uninfected mosquitoes of different ages. Wolbachia-infected mosquitoes exhibit greater expression of some genes related to the melanization pathway, but not for those directly linked to dopamine production. Although dopamine levels were higher in Wolbachia-positive mosquitoes this was not consistent across all insect ages nor was it related to the previously described Wolbachia induced bendy and shaky phenotypes.

AB - Wolbachia is an intracellular bacterium that has been stably transinfected into the mosquito vector of dengue, Aedes aegypti. This inherited infection causes a range of metabolic and phenotypic alterations in the mosquito, which might be related to neuronal abnormalities. In order to determine if these alterations were caused by the manipulation of neuroamines by this bacterium, we studied the expression of genes involved in the dopamine biosynthetic pathway and also measured the amount of dopamine in infected and uninfected mosquitoes of different ages. Wolbachia-infected mosquitoes exhibit greater expression of some genes related to the melanization pathway, but not for those directly linked to dopamine production. Although dopamine levels were higher in Wolbachia-positive mosquitoes this was not consistent across all insect ages nor was it related to the previously described Wolbachia induced bendy and shaky phenotypes.

UR - http://www.parasitesandvectors.com/content/pdf/1756-3305-4-28.pdf

U2 - 10.1186/1756-3305-4-28

DO - 10.1186/1756-3305-4-28

M3 - Article

SN - 1756-3305

VL - 4

JO - Parasites & Vectors

JF - Parasites & Vectors

M1 - 28

ER -

The wMelPop strain of Wolbachia interferes with dopamine levels in Aedes aegypti

Abstract

UN SDGs

Access to Document

Other files and links

Cite this