The validity of bioelectrical impedance analysis to measure body composition in phenylketonuria

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Abstract

Aim: To compare the measurement of total body water (TBW) and fat-free mass (FFM) using the criterion method of deuterium dilution space (2H2O) with bioelectrical impedance analysis (BIA) using a portable QuadScan 4000, Bodystat® in children and adolescents with phenylketonuria (PKU). Methods: Sixteen patients with PKU, median age is 12.5 (range 5–20.6) years, were recruited into this cross-sectional study. TBW was measured by both deuterium dilution and BIA on the same occasion as per a standard protocol. FFM was estimated from predictive equations. Results: There was no significant difference between TBWDeut and TBWBIA (p = 0.344) or FFMDeut and FFMBIA (p = 0.111). TBWDeut and TBWBIA were highly correlated (r = 0.990, p < 0.0001), as were FFMDeut and FFMBIA (r = 0.984, p < 0.0001). Bland-Altman plots demonstrated that there was no proportional bias between the criterion method, TBWDeut, and the test method TBWBIA, in estimating TBW (β = −0.056, adjusted r2 = 0.069, p = 0.169) or FFM (β = −0.089, adjusted r2 = 0.142, p = 0.083). Conclusion: Our results suggest that when compared with the criterion method, the QuadScan 4000, Bodystat® can reliably be used to predict TBW and FFM in patients with PKU. We suggest that due to the portability and non-invasive approach, this method can reliably be used to monitor body composition in the outpatient clinic setting, to further improve the monitoring and assessment of nutritional status in PKU.

Original languageEnglish
Title of host publicationJIMD Reports
EditorsEva Morava, Matthias Baumgartner
Place of PublicationBerlin, Heidelberg
PublisherSpringer
Pages37-45
Number of pages9
ISBN (Electronic)9783662583654
ISBN (Print)9783662583647
DOIs
Publication statusPublished - 1 Jan 2018

Publication series

NameJIMD Reports
Volume42
ISSN (Print)2192-8304
ISSN (Electronic)2192-8312

Keywords

  • Bioelectrical impedance analysis
  • Body composition
  • Deuterium dilution
  • Fat-free mass
  • Phenylketonuria
  • Total body water

Cite this

Evans, M., Nguo, K., Boneh, A., & Truby, H. (2018). The validity of bioelectrical impedance analysis to measure body composition in phenylketonuria. In E. Morava, & M. Baumgartner (Eds.), JIMD Reports (pp. 37-45). (JIMD Reports; Vol. 42). Berlin, Heidelberg: Springer. https://doi.org/10.1007/8904_2017_75
Evans, Maureen ; Nguo, Kay ; Boneh, Avihu ; Truby, Helen. / The validity of bioelectrical impedance analysis to measure body composition in phenylketonuria. JIMD Reports. editor / Eva Morava ; Matthias Baumgartner. Berlin, Heidelberg : Springer, 2018. pp. 37-45 (JIMD Reports).
@inbook{8a83872a4de549fcac5f128fc9c2eb86,
title = "The validity of bioelectrical impedance analysis to measure body composition in phenylketonuria",
abstract = "Aim: To compare the measurement of total body water (TBW) and fat-free mass (FFM) using the criterion method of deuterium dilution space (2H2O) with bioelectrical impedance analysis (BIA) using a portable QuadScan 4000, Bodystat{\circledR} in children and adolescents with phenylketonuria (PKU). Methods: Sixteen patients with PKU, median age is 12.5 (range 5–20.6) years, were recruited into this cross-sectional study. TBW was measured by both deuterium dilution and BIA on the same occasion as per a standard protocol. FFM was estimated from predictive equations. Results: There was no significant difference between TBWDeut and TBWBIA (p = 0.344) or FFMDeut and FFMBIA (p = 0.111). TBWDeut and TBWBIA were highly correlated (r = 0.990, p < 0.0001), as were FFMDeut and FFMBIA (r = 0.984, p < 0.0001). Bland-Altman plots demonstrated that there was no proportional bias between the criterion method, TBWDeut, and the test method TBWBIA, in estimating TBW (β = −0.056, adjusted r2 = 0.069, p = 0.169) or FFM (β = −0.089, adjusted r2 = 0.142, p = 0.083). Conclusion: Our results suggest that when compared with the criterion method, the QuadScan 4000, Bodystat{\circledR} can reliably be used to predict TBW and FFM in patients with PKU. We suggest that due to the portability and non-invasive approach, this method can reliably be used to monitor body composition in the outpatient clinic setting, to further improve the monitoring and assessment of nutritional status in PKU.",
keywords = "Bioelectrical impedance analysis, Body composition, Deuterium dilution, Fat-free mass, Phenylketonuria, Total body water",
author = "Maureen Evans and Kay Nguo and Avihu Boneh and Helen Truby",
year = "2018",
month = "1",
day = "1",
doi = "10.1007/8904_2017_75",
language = "English",
isbn = "9783662583647",
series = "JIMD Reports",
publisher = "Springer",
pages = "37--45",
editor = "Morava, {Eva } and Baumgartner, {Matthias }",
booktitle = "JIMD Reports",

}

Evans, M, Nguo, K, Boneh, A & Truby, H 2018, The validity of bioelectrical impedance analysis to measure body composition in phenylketonuria. in E Morava & M Baumgartner (eds), JIMD Reports. JIMD Reports, vol. 42, Springer, Berlin, Heidelberg, pp. 37-45. https://doi.org/10.1007/8904_2017_75

The validity of bioelectrical impedance analysis to measure body composition in phenylketonuria. / Evans, Maureen; Nguo, Kay; Boneh, Avihu; Truby, Helen.

JIMD Reports. ed. / Eva Morava; Matthias Baumgartner. Berlin, Heidelberg : Springer, 2018. p. 37-45 (JIMD Reports; Vol. 42).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

TY - CHAP

T1 - The validity of bioelectrical impedance analysis to measure body composition in phenylketonuria

AU - Evans, Maureen

AU - Nguo, Kay

AU - Boneh, Avihu

AU - Truby, Helen

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Aim: To compare the measurement of total body water (TBW) and fat-free mass (FFM) using the criterion method of deuterium dilution space (2H2O) with bioelectrical impedance analysis (BIA) using a portable QuadScan 4000, Bodystat® in children and adolescents with phenylketonuria (PKU). Methods: Sixteen patients with PKU, median age is 12.5 (range 5–20.6) years, were recruited into this cross-sectional study. TBW was measured by both deuterium dilution and BIA on the same occasion as per a standard protocol. FFM was estimated from predictive equations. Results: There was no significant difference between TBWDeut and TBWBIA (p = 0.344) or FFMDeut and FFMBIA (p = 0.111). TBWDeut and TBWBIA were highly correlated (r = 0.990, p < 0.0001), as were FFMDeut and FFMBIA (r = 0.984, p < 0.0001). Bland-Altman plots demonstrated that there was no proportional bias between the criterion method, TBWDeut, and the test method TBWBIA, in estimating TBW (β = −0.056, adjusted r2 = 0.069, p = 0.169) or FFM (β = −0.089, adjusted r2 = 0.142, p = 0.083). Conclusion: Our results suggest that when compared with the criterion method, the QuadScan 4000, Bodystat® can reliably be used to predict TBW and FFM in patients with PKU. We suggest that due to the portability and non-invasive approach, this method can reliably be used to monitor body composition in the outpatient clinic setting, to further improve the monitoring and assessment of nutritional status in PKU.

AB - Aim: To compare the measurement of total body water (TBW) and fat-free mass (FFM) using the criterion method of deuterium dilution space (2H2O) with bioelectrical impedance analysis (BIA) using a portable QuadScan 4000, Bodystat® in children and adolescents with phenylketonuria (PKU). Methods: Sixteen patients with PKU, median age is 12.5 (range 5–20.6) years, were recruited into this cross-sectional study. TBW was measured by both deuterium dilution and BIA on the same occasion as per a standard protocol. FFM was estimated from predictive equations. Results: There was no significant difference between TBWDeut and TBWBIA (p = 0.344) or FFMDeut and FFMBIA (p = 0.111). TBWDeut and TBWBIA were highly correlated (r = 0.990, p < 0.0001), as were FFMDeut and FFMBIA (r = 0.984, p < 0.0001). Bland-Altman plots demonstrated that there was no proportional bias between the criterion method, TBWDeut, and the test method TBWBIA, in estimating TBW (β = −0.056, adjusted r2 = 0.069, p = 0.169) or FFM (β = −0.089, adjusted r2 = 0.142, p = 0.083). Conclusion: Our results suggest that when compared with the criterion method, the QuadScan 4000, Bodystat® can reliably be used to predict TBW and FFM in patients with PKU. We suggest that due to the portability and non-invasive approach, this method can reliably be used to monitor body composition in the outpatient clinic setting, to further improve the monitoring and assessment of nutritional status in PKU.

KW - Bioelectrical impedance analysis

KW - Body composition

KW - Deuterium dilution

KW - Fat-free mass

KW - Phenylketonuria

KW - Total body water

UR - http://www.scopus.com/inward/record.url?scp=85060330706&partnerID=8YFLogxK

U2 - 10.1007/8904_2017_75

DO - 10.1007/8904_2017_75

M3 - Chapter (Book)

SN - 9783662583647

T3 - JIMD Reports

SP - 37

EP - 45

BT - JIMD Reports

A2 - Morava, Eva

A2 - Baumgartner, Matthias

PB - Springer

CY - Berlin, Heidelberg

ER -

Evans M, Nguo K, Boneh A, Truby H. The validity of bioelectrical impedance analysis to measure body composition in phenylketonuria. In Morava E, Baumgartner M, editors, JIMD Reports. Berlin, Heidelberg: Springer. 2018. p. 37-45. (JIMD Reports). https://doi.org/10.1007/8904_2017_75