TY - CHAP
T1 - The validity of bioelectrical impedance analysis to measure body composition in phenylketonuria
AU - Evans, Maureen
AU - Nguo, Kay
AU - Boneh, Avihu
AU - Truby, Helen
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Aim: To compare the measurement of total body water (TBW) and fat-free mass (FFM) using the criterion method of deuterium dilution space (2H2O) with bioelectrical impedance analysis (BIA) using a portable QuadScan 4000, Bodystat® in children and adolescents with phenylketonuria (PKU). Methods: Sixteen patients with PKU, median age is 12.5 (range 5–20.6) years, were recruited into this cross-sectional study. TBW was measured by both deuterium dilution and BIA on the same occasion as per a standard protocol. FFM was estimated from predictive equations. Results: There was no significant difference between TBWDeut and TBWBIA (p = 0.344) or FFMDeut and FFMBIA (p = 0.111). TBWDeut and TBWBIA were highly correlated (r = 0.990, p < 0.0001), as were FFMDeut and FFMBIA (r = 0.984, p < 0.0001). Bland-Altman plots demonstrated that there was no proportional bias between the criterion method, TBWDeut, and the test method TBWBIA, in estimating TBW (β = −0.056, adjusted r2 = 0.069, p = 0.169) or FFM (β = −0.089, adjusted r2 = 0.142, p = 0.083). Conclusion: Our results suggest that when compared with the criterion method, the QuadScan 4000, Bodystat® can reliably be used to predict TBW and FFM in patients with PKU. We suggest that due to the portability and non-invasive approach, this method can reliably be used to monitor body composition in the outpatient clinic setting, to further improve the monitoring and assessment of nutritional status in PKU.
AB - Aim: To compare the measurement of total body water (TBW) and fat-free mass (FFM) using the criterion method of deuterium dilution space (2H2O) with bioelectrical impedance analysis (BIA) using a portable QuadScan 4000, Bodystat® in children and adolescents with phenylketonuria (PKU). Methods: Sixteen patients with PKU, median age is 12.5 (range 5–20.6) years, were recruited into this cross-sectional study. TBW was measured by both deuterium dilution and BIA on the same occasion as per a standard protocol. FFM was estimated from predictive equations. Results: There was no significant difference between TBWDeut and TBWBIA (p = 0.344) or FFMDeut and FFMBIA (p = 0.111). TBWDeut and TBWBIA were highly correlated (r = 0.990, p < 0.0001), as were FFMDeut and FFMBIA (r = 0.984, p < 0.0001). Bland-Altman plots demonstrated that there was no proportional bias between the criterion method, TBWDeut, and the test method TBWBIA, in estimating TBW (β = −0.056, adjusted r2 = 0.069, p = 0.169) or FFM (β = −0.089, adjusted r2 = 0.142, p = 0.083). Conclusion: Our results suggest that when compared with the criterion method, the QuadScan 4000, Bodystat® can reliably be used to predict TBW and FFM in patients with PKU. We suggest that due to the portability and non-invasive approach, this method can reliably be used to monitor body composition in the outpatient clinic setting, to further improve the monitoring and assessment of nutritional status in PKU.
KW - Bioelectrical impedance analysis
KW - Body composition
KW - Deuterium dilution
KW - Fat-free mass
KW - Phenylketonuria
KW - Total body water
UR - http://www.scopus.com/inward/record.url?scp=85060330706&partnerID=8YFLogxK
U2 - 10.1007/8904_2017_75
DO - 10.1007/8904_2017_75
M3 - Chapter (Book)
AN - SCOPUS:85060330706
SN - 9783662583647
T3 - JIMD Reports
SP - 37
EP - 45
BT - JIMD Reports
A2 - Morava, Eva
A2 - Baumgartner, Matthias
PB - Springer
CY - Berlin, Heidelberg
ER -