The use of snake venom toxins as tools to study platelet receptors for collagen and von Willebrand factor

Robert K. Andrews, Aura S. Kamiguti, Oscar Berlanga, Mireille Leduc, R. David G. Theakston, Steve P. Watson

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Abstract

A large proportion of the biologically active proteins and peptides present within snake venoms interact with components of the haemostatic system to promote or inhibit the normal sequence of events that lead to clot formation. The venom proteins achieve their effects through interaction with various components of the coagulation cascade, endothelial matrix and platelets. Within the latter group, a number of venom proteins target the interaction of platelets with the major adhesive proteins, von Willebrand factor and collagen. The venom proteins bind either the adhesive protein itself or their receptors on the platelet surface, notably GP-Ib-IX-V and GPVI. This review discusses the substantial contribution that venom proteins have made to our understanding of the role of these two adhesive proteins and their receptors (excluding GPIIb-IIIa) in platelet regulation.

Original languageEnglish
Pages (from-to)155-172
Number of pages18
JournalHaemostasis
Volume31
Issue number3-6
Publication statusPublished - 1 Dec 2001
Externally publishedYes

Keywords

  • Botrocetin
  • C-type lectin
  • Collagen
  • Convulxin
  • GPIb-IX-V
  • GPVI
  • Metalloproteinase
  • Snake toxin
  • von Willebrand factor

Cite this