The use of signalling pathway inhibitors and chromatin modifiers for enhancing pluripotency

Huseyin Sumer, Jun Liu, Paul Verma

    Research output: Contribution to journalArticleResearchpeer-review

    6 Citations (Scopus)

    Abstract

    Pluripotent embryonic stem cells have been isolated from a limited number of species. The new advances with inducing pluripotency in somatic cells have resulted in the generation of pluripotent stem cells while circumventing the need for embryos. In this review we describe the main signalling pathways involved in maintaining pluripotency and inducing differentiation. Inhibition of the signalling pathways involved in differentiation enhances the derivation and cultivation of pluripotent stem cells. Furthermore, we discuss the use of chromatin modifiers to maintain an open chromatin state which is characteristic of pluripotent stem cells, to facilitate the derivation of pluripotent cell lines.
    Original languageEnglish
    Pages (from-to)525 - 533
    Number of pages9
    JournalTheriogenology
    Volume74
    Issue number4
    DOIs
    Publication statusPublished - 2010

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