The use of Resonant X-ray Emission Spectroscopy (RXES) for the electronic analysis of metal complexes and their interactions with biomolecules

Jacinto Sa, Joanna Czapla, Ewelina Wioletta Lipiec, Yves Kayser, Wojciech M Kwiatek, Bayden Robert Wood, Glen Berenger Deacon, Gilles Berger, Francois Dufrasne, Daniel Luis Abreu Fernandes, Jakub Szlachetko

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This review presents a new application of Resonant X-ray Emission Spectroscopy (RXES) to study the mechanism of action of metal containing anticancer derivatives and in particular platinum in situ and in vivo. The technique is an example of a photon-in photon-out X-ray spectroscopic approach, which enables chemical speciation of drugs to be determined and therefore to derive action mechanisms, and to determine drug binding rates under physiological conditions and therapeutic concentrations. This is made feasible due to the atomic specificity and high penetration depth of RXES. The review presents examples of the three main types of information that can be obtained by RXES and establishes an experimental protocol to perfect the measurements within cells
Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalDrug Discovery Today: Technologies
Publication statusPublished - 2015

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