The use of Resonant X-ray Emission Spectroscopy (RXES) for the electronic analysis of metal complexes and their interactions with biomolecules

Jacinto Sa; Joanna Czapla; Ewelina Wioletta Lipiec; Yves Kayser; Wojciech M Kwiatek; Bayden Robert Wood; Glen Berenger Deacon; Gilles Berger; Francois Dufrasne; Daniel Luis Abreu Fernandes; Jakub Szlachetko

doi:10.1016/j.ddtec.2015.07.001

The use of Resonant X-ray Emission Spectroscopy (RXES) for the electronic analysis of metal complexes and their interactions with biomolecules

Jacinto Sa, Joanna Czapla, Ewelina Wioletta Lipiec, Yves Kayser, Wojciech M Kwiatek, Bayden Robert Wood, Glen Berenger Deacon, Gilles Berger, Francois Dufrasne, Daniel Luis Abreu Fernandes, Jakub Szlachetko

School of Chemistry

Research output: Contribution to journal › Article › Research › peer-review

2 Citations (Scopus)

Abstract

This review presents a new application of Resonant X-ray Emission Spectroscopy (RXES) to study the mechanism of action of metal containing anticancer derivatives and in particular platinum in situ and in vivo. The technique is an example of a photon-in photon-out X-ray spectroscopic approach, which enables chemical speciation of drugs to be determined and therefore to derive action mechanisms, and to determine drug binding rates under physiological conditions and therapeutic concentrations. This is made feasible due to the atomic specificity and high penetration depth of RXES. The review presents examples of the three main types of information that can be obtained by RXES and establishes an experimental protocol to perfect the measurements within cells

Original language	English
Pages (from-to)	1-6
Number of pages	6
Journal	Drug Discovery Today: Technologies
Volume	16
DOIs	https://doi.org/10.1016/j.ddtec.2015.07.001
Publication status	Published - 2015

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10.1016/j.ddtec.2015.07.001

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Sa, J., Czapla, J., Lipiec, E. W., Kayser, Y., Kwiatek, W. M., Wood, B. R., Deacon, G. B., Berger, G., Dufrasne, F., Fernandes, D. L. A., & Szlachetko, J. (2015). The use of Resonant X-ray Emission Spectroscopy (RXES) for the electronic analysis of metal complexes and their interactions with biomolecules. Drug Discovery Today: Technologies, 16, 1-6. https://doi.org/10.1016/j.ddtec.2015.07.001

@article{74fe87f8c2f148ceb4daea9d6571238a,

title = "The use of Resonant X-ray Emission Spectroscopy (RXES) for the electronic analysis of metal complexes and their interactions with biomolecules",

abstract = "This review presents a new application of Resonant X-ray Emission Spectroscopy (RXES) to study the mechanism of action of metal containing anticancer derivatives and in particular platinum in situ and in vivo. The technique is an example of a photon-in photon-out X-ray spectroscopic approach, which enables chemical speciation of drugs to be determined and therefore to derive action mechanisms, and to determine drug binding rates under physiological conditions and therapeutic concentrations. This is made feasible due to the atomic specificity and high penetration depth of RXES. The review presents examples of the three main types of information that can be obtained by RXES and establishes an experimental protocol to perfect the measurements within cells",

author = "Jacinto Sa and Joanna Czapla and Lipiec, {Ewelina Wioletta} and Yves Kayser and Kwiatek, {Wojciech M} and Wood, {Bayden Robert} and Deacon, {Glen Berenger} and Gilles Berger and Francois Dufrasne and Fernandes, {Daniel Luis Abreu} and Jakub Szlachetko",

year = "2015",

doi = "10.1016/j.ddtec.2015.07.001",

language = "English",

volume = "16",

pages = "1--6",

journal = "Drug Discovery Today: Technologies",

issn = "1740-6749",

publisher = "Elsevier",

}

Sa, J, Czapla, J, Lipiec, EW, Kayser, Y, Kwiatek, WM, Wood, BR , Deacon, GB, Berger, G, Dufrasne, F, Fernandes, DLA & Szlachetko, J 2015, 'The use of Resonant X-ray Emission Spectroscopy (RXES) for the electronic analysis of metal complexes and their interactions with biomolecules', Drug Discovery Today: Technologies, vol. 16, pp. 1-6. https://doi.org/10.1016/j.ddtec.2015.07.001

TY - JOUR

T1 - The use of Resonant X-ray Emission Spectroscopy (RXES) for the electronic analysis of metal complexes and their interactions with biomolecules

AU - Sa, Jacinto

AU - Czapla, Joanna

AU - Lipiec, Ewelina Wioletta

AU - Kayser, Yves

AU - Kwiatek, Wojciech M

AU - Wood, Bayden Robert

AU - Deacon, Glen Berenger

AU - Berger, Gilles

AU - Dufrasne, Francois

AU - Fernandes, Daniel Luis Abreu

AU - Szlachetko, Jakub

PY - 2015

Y1 - 2015

N2 - This review presents a new application of Resonant X-ray Emission Spectroscopy (RXES) to study the mechanism of action of metal containing anticancer derivatives and in particular platinum in situ and in vivo. The technique is an example of a photon-in photon-out X-ray spectroscopic approach, which enables chemical speciation of drugs to be determined and therefore to derive action mechanisms, and to determine drug binding rates under physiological conditions and therapeutic concentrations. This is made feasible due to the atomic specificity and high penetration depth of RXES. The review presents examples of the three main types of information that can be obtained by RXES and establishes an experimental protocol to perfect the measurements within cells

AB - This review presents a new application of Resonant X-ray Emission Spectroscopy (RXES) to study the mechanism of action of metal containing anticancer derivatives and in particular platinum in situ and in vivo. The technique is an example of a photon-in photon-out X-ray spectroscopic approach, which enables chemical speciation of drugs to be determined and therefore to derive action mechanisms, and to determine drug binding rates under physiological conditions and therapeutic concentrations. This is made feasible due to the atomic specificity and high penetration depth of RXES. The review presents examples of the three main types of information that can be obtained by RXES and establishes an experimental protocol to perfect the measurements within cells

UR - http://goo.gl/niYJ1y

U2 - 10.1016/j.ddtec.2015.07.001

DO - 10.1016/j.ddtec.2015.07.001

M3 - Article

C2 - 26547415

SN - 1740-6749

VL - 16

SP - 1

EP - 6

JO - Drug Discovery Today: Technologies

JF - Drug Discovery Today: Technologies

ER -

The use of Resonant X-ray Emission Spectroscopy (RXES) for the electronic analysis of metal complexes and their interactions with biomolecules

Abstract

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Spectroscopic investigations into nano-scale drug interactions and molecular processes in single living cells and isolated molecules

Coupling biophotonic modalities with machine based recognition systems for disease diagnosis

Cite this

The use of Resonant X-ray Emission Spectroscopy (RXES) for the electronic analysis of metal complexes and their interactions with biomolecules

Abstract

Access to Document

Other files and links

Projects

Spectroscopic investigations into nano-scale drug interactions and molecular processes in single living cells and isolated molecules

Coupling biophotonic modalities with machine based recognition systems for disease diagnosis

Cite this