@inbook{4d0e14d453304a6fb10c6fc4fe42785b,
title = "The use of L-sIDOL transgenic mice as a murine model to study hypercholesterolemia and atherosclerosis",
abstract = "There are many advantages to the use of mice as a model to study the regulation of cholesterol metabolism. Common models of hypercholesterolemia include low-density lipoprotein receptor deficient (LDLR −/−) mice and apolipoprotein E deficient (ApoE) −/− mice. Herein, we describe the recently generated mouse model, L-sIDOL Tg mice, which express a dominant active form of Inducible Degrader Of the Low-density lipoprotein receptor (IDOL) in a liver-specific manner. This murine model offers significant advantages over previously established models for the study of hypercholesterolemia and atherosclerosis.",
keywords = "Atherosclerosis, Hypercholesterolemia, IDOL, LDL cholesterol, LDLR, Liver, Mouse model, Transgenic",
author = "Zerenturk, \{Eser J.\} and Calkin, \{Anna C.\}",
year = "2017",
doi = "10.1007/978-1-4939-6875-6\_6",
language = "English",
isbn = "9781493968732 ",
series = "Methods in Molecular Biology",
publisher = "Humana Press",
pages = "65--72",
booktitle = "Cholesterol Homeostasis",
address = "United States of America",
}