The use of L-sIDOL transgenic mice as a murine model to study hypercholesterolemia and atherosclerosis

Eser J. Zerenturk, Anna C. Calkin

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Abstract

There are many advantages to the use of mice as a model to study the regulation of cholesterol metabolism. Common models of hypercholesterolemia include low-density lipoprotein receptor deficient (LDLR −/−) mice and apolipoprotein E deficient (ApoE) −/− mice. Herein, we describe the recently generated mouse model, L-sIDOL Tg mice, which express a dominant active form of Inducible Degrader Of the Low-density lipoprotein receptor (IDOL) in a liver-specific manner. This murine model offers significant advantages over previously established models for the study of hypercholesterolemia and atherosclerosis.

Original languageEnglish
Title of host publicationCholesterol Homeostasis
Subtitle of host publicationMethods and Protocols
Place of PublicationNew York, NY
PublisherHumana Press
Chapter6
Pages65-72
Number of pages8
ISBN (Electronic)9781493968756
ISBN (Print)9781493968732
DOIs
Publication statusPublished - 2017

Publication series

NameMethods in Molecular Biology
Volume1583
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Keywords

  • Atherosclerosis
  • Hypercholesterolemia
  • IDOL
  • LDL cholesterol
  • LDLR
  • Liver
  • Mouse model
  • Transgenic

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