THE USE OF INTERNALIZABLE DERIVATIVES OF CHLORIN E6 FOR INCREASING ITS PHOTOSENSITIZING ACTIVITY

Tamara V. Akhlynina, Andrey A. Rosenkranz, David A. Jans, Pavel V. Gulak, Natalia V. Sererryakova, Alexander S. Sobolev

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Abstract

Experiments with human hepatoma PLC/PRF/5 cells and human embryo skin fibroblasts involving the use of three different tests (colony formation, Trypan blue exclusion, labeled thymidine incorporation) have demonstrated a significantly higher photosensitizing activity of chlorin e6 conjugates with internalizable ligands as compared to that of chlorin e6 itself. Receptor‐mediated internalization of chlorin e6 conjugates ensures a greater photosensitization of cells than binding of those conjugates to cell surface receptors. The suitability of such conjugates that permit the delivery of a photosensitizer to sensitive intracellular targets is discussed.

Original languageEnglish
Pages (from-to)45-48
Number of pages4
JournalPhotochemistry and Photobiology
Volume58
Issue number1
DOIs
Publication statusPublished - 1 Jan 1993
Externally publishedYes

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